R. Santos

Byproducts of inflammatory radical metabolism provide transient nutrient niches for microbes in the inflamed gut

The paper investigates how inflammatory radicals generate tartaric acid isomers, which serve as transient nutrients for gut pathogens in murine models.

Spatial structure formation by RsmE-regulated extracellular secretions in Pseudomonas fluorescens Pf0-1

This study shows that RsmE-regulated secretions in Pseudomonas fluorescens Pf0-1 create and protect low-density spaces, with biosurfactant gacamide A defining genotypic boundaries.

Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Fornicata

The paper characterizes endocytic compartments in Giardia lamblia using microscopy and phylogenetic analysis, revealing loss of clathrin light chain and emergence of a CLC analog in the Fornicata lineage.

Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata

The kallikrein-kinin system is falling into pieces: bradykinin fragments are biological active peptides

This study investigates the biological activity of bradykinin fragments and finds they induce nitric oxide production and vasorelaxation independently of classical kinin receptors.

Design of 18 nm Doxorubicin-loaded 3-helix Micelles: Cellular Uptake and Cytotoxicity in Patient-derived GBM6 Cells

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening

This study uses CRISPR-Cas9 screens in cancer cell lines to identify and prioritize new oncology therapeutic targets based on gene fitness, biomarkers, and tractability.

Elevated trace elements in Posidonia oceanica and Cymodocea nodosa at six Mediterranean volcanic seeps

The paper assesses trace element accumulation in seagrasses and sediments at Mediterranean CO2 seeps, finding elevated levels in some sites and linking them to potential adverse impacts on marine biota.

Identification of a Small Molecule Inhibitor of the Aminoglycoside 6’-N-Acetyltransferase Type Ib [AAC(6’)-Ib] Using Mixture-Based Combinatorial Libraries

The paper identifies a small molecule inhibitor of AAC(6’)-Ib using combinatorial libraries and evaluates its efficacy against antibiotic-resistant bacteria.