Author

D. A. Jackson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

D. G. Spiller· 2 shared E. Goncalves· 2 shared H. England· 2 shared P. Paszek· 2 shared R. Ansari· 2 shared A. Barthorpe· 1 shared A. Beck· 1 shared A. D. Adamson· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

D. G. Spiller

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Overexpression of IkappaBalpha modulates NF-kappaB activation of inflammatory target gene expression

P. Downton, J. S. Bagnall, H. England, D. G. Spiller, N. Humphreys, D. A. Jackson, P. Paszek, M. R. H. White, A. D. Adamson

This study shows that overexpression of IκBα reduces inflammatory gene expression by inhibiting p65 promoter binding, even when p65 dynamics remain intact.

bioRxiv · Mar 14, 2023Cell Biology

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

S. Price, S. G. Bhosle, E. Goncalves, X. Li, D. McClurg, A. Barthorpe, A. Beck, C. Hall, H. Lightfoot, L. Farrow, R. Ansari, D. A. Jackson, L. Allen, K. Roberts, C. Beaver, , M. Garnett

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

bioRxiv · Oct 23, 2021Cancer Biology

Targeting IL-6 reduces IgM levels and tumor growth in Waldenstrom macroglobulinemia

W. Han, S. J. Matissek, D. A. Jackson, B. Sklavanitis, S. F. Elsawa

This study shows that Tocilizumab reduces tumor growth and IgM secretion in a mouse model of Waldenstrom macroglobulinemia by targeting IL-6.

bioRxiv · Apr 2, 2019Cancer Biology

Macrophage-specific NF-kappa B activation dynamics can segregate inflammatory bowel disease patients

S. Papoutsopoulou, M. D. Burkitt, F. Bergey, H. England, R. Hough, L. Schmidt, D. G. Spiller, M. H. White, P. Paszek, D. A. Jackson, V. A. Martins Dos Santos, G. Sellge, D. M. Pritchard, B. J. Campbell, W. Muller, C. Probert

This paper uses dynamic NF-kappaB activation assays in macrophages to stratify IBD patients into distinct phenotypic groups based on their response to stimulation.

bioRxiv · Jan 30, 2019Immunology

Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening

F. M. Behan, F. Iorio, E. Goncalves, G. Picco, C. M. Beaver, R. Santos, Y. Rao, R. Ansari, S. Harper, D. A. Jackson, R. McRae, R. Pooley, P. Wilkinson, D. Dow, C. Buser-Doepner, , G. J. Mathew

This study uses CRISPR-Cas9 screens in cancer cell lines to identify and prioritize new oncology therapeutic targets based on gene fitness, biomarkers, and tractability.

bioRxiv · Dec 20, 2018Cancer Biology