Pre-existing SIV infection increases expression of T cell markers associated with activation during early Mycobacterium tuberculosis co-infection and impairs TNF responses in granulomas
E. Larson, A. L. Ellis, M. A. Rodgers, A. J. Balgeman, R. V. Moriarty, C. Ameel, T. Baranowski, J. Tomko, C. Causgrove, P. Maiello, S. L. OConnor, C. A. Scanga
This study shows that pre-existing SIV infection alters T cell phenotypes and reduces TNF responses during early Mtb co-infection, impairing immune control.
bioRxiv · Dec 14, 2020Immunology