Author

E. Larson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Ecology· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

N. Van Hoeven· 2 shared A. Gerhardt· 1 shared A. H. Asseri· 1 shared A. J. Balgeman· 1 shared A. Khandhar· 1 shared A. L. Ellis· 1 shared A. Rahlin· 1 shared B. Doranz· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBioengineering

N. Van Hoeven

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identification of Natural Antiviral Drug Candidates Against Tilapia Lake Virus: Computational Drug Design Approaches

C. L. Brown, M. A. A. Sumon, A. H. Asseri, M. H. R. Molla, M. O. Aljahdali, M. R. Hasan, M. A. Rahman, M. T. Hasan, T. A. Sumon, M. H. Gabr, M. S. Islam, B. Fakhurji, M. Moulay, E. Larson

This study identifies potential antiviral compounds from two mangrove plants targeting CRM1 protein to inhibit Tilapia Lake Virus using computational methods.

bioRxiv · Jun 19, 2023Pharmacology & Toxicology

Chronic obstructive pulmonary disease and cigarette smoke exposure lead to dysregulated MAIT cell activation by bronchial epithelial cells

M. E. Huber, E. Larson, T. N. Lust, C. M. Heisler, M. J. Harriff

This study shows that chronic obstructive pulmonary disease and cigarette smoke exposure alter MAIT cell activation by bronchial epithelial cells, leading to dysregulated immune responses.

bioRxiv · Feb 28, 2022 · PreprintImmunology

Stage-specific disruption of X chromosome expression during spermatogenesis in sterile house mouse hybrids

E. Larson, E. E. K. Kopania, K. E. Hunnicutt, D. Vanderpool, S. Keeble, J. M. Good

This study investigates X chromosome expression disruption in sterile house mouse hybrids during spermatogenesis, identifying stage-specific gene regulation issues linked to hybrid sterility mechanisms.

bioRxiv · Nov 12, 2021Evolutionary Biology

A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response

A. Gerhardt, E. Voigt, M. Archer, S. Reed, E. Larson, N. Van Hoeven, R. Kramer, C. Fox, C. Casper

This paper introduces a thermostable RNA vaccine delivery system stable at room temperature for 8+ months and refrigerated for 21+ months, improving vaccine distribution in low-resource settings.

bioRxiv · Feb 1, 2021Bioengineering

Pre-existing SIV infection increases expression of T cell markers associated with activation during early Mycobacterium tuberculosis co-infection and impairs TNF responses in granulomas

E. Larson, A. L. Ellis, M. A. Rodgers, A. J. Balgeman, R. V. Moriarty, C. Ameel, T. Baranowski, J. Tomko, C. Causgrove, P. Maiello, S. L. OConnor, C. A. Scanga

This study shows that pre-existing SIV infection alters T cell phenotypes and reduces TNF responses during early Mtb co-infection, impairing immune control.

bioRxiv · Dec 14, 2020Immunology

Integrated technology platform for accelerated discovery of antiviral antibody therapeutics

P. Gilchuk, R. G. Bombardi, J. H. Erasmus, Q. Tan, R. S. Nargi, C. Soto, P. Abbink, T. J. Suscovich, L. A. Dunellin, A. Khandhar, J. Archer, J. Liang, M. E. Fouch, E. Davidson, B. Doranz, , R. H. Carnahan

This study develops an integrated platform to rapidly discover and validate potent antiviral human monoclonal antibodies against Zika virus.

bioRxiv · May 12, 2020Immunology

Data-based, synthesis-driven: setting the agenda for computational ecology

T. Poisot, R. Labrie, E. Larson, A. Rahlin

The paper discusses the integration of computational methods in ecology, emphasizing the need for dialogue between empirical ecologists, modellers, and computational ecologists to improve data standards, model predictions, and data credit.

bioRxiv · Jul 9, 2018Ecology