Structural insights into p300 regulation and acetylation-dependent genome organisation
Z. Ibrahim, T. Wang, O. Destaing, N. Salvi, N. Hoghoughi, C. Chabert, A. D. Rusu, J. Gao, L. Feletto, N. Reynoird, T. Schalch, Y. Zhao, M. Blackledge, S. Khochbin, D. Panne
The paper investigates how acetylation reading and writing enable long-range chromosomal interactions through the BRD4-NUT oncogenic fusion protein and p300 activation.
bioRxiv · Mar 14, 2022Biochemistry