M. Blackledge

A specific phosphorylation-dependent conformational switch of SARS-CoV-2 nucleoprotein inhibits RNA binding

This study identifies a phosphorylation-dependent conformational switch in SARS-CoV-2 nucleoprotein that inhibits RNA binding by altering domain interactions.

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

This study characterizes the multivalent interactions of XRCC4 and XLF CTRs, showing they form condensates that enhance DNA ligation in vitro and suggest roles in NHEJ dynamics and cancer biology.

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.

Phase separation and molecular ordering of the prion-like domain of the thermosensory protein EARLY FLOWERING 3

The paper investigates the phase separation behavior of the prion-like domain of ELF3 in Arabidopsis, showing how polyQ length affects structural transitions and hydrogel formation.

A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

Structural insights into p300 regulation and acetylation-dependent genome organisation

The paper investigates how acetylation reading and writing enable long-range chromosomal interactions through the BRD4-NUT oncogenic fusion protein and p300 activation.

Binding stoichiometry and structural model of the HIV-1 Rev/Importin beta complex

This study determines the binding stoichiometry and structural model of the HIV-1 Rev/Importin beta complex using biochemical and biophysical methods.

Molecular Basis of Host-Adaptation Interactions between Influenza Virus Polymerase PB2 Subunit and ANP32A

This study identifies molecular interactions between influenza PB2 subunit variants and ANP32A that explain host adaptation and species-specific restriction of viral replication.