TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy
P. Hamon, M. Gerbe de Thore, M. Classe, N. Signolle, W. Liu, O. Bawa, L. Meziani, C. Clemenson, F. Milliat, E. Deutsch, M. Mondini
This study shows that inhibiting TGFβ receptors in tumor-associated macrophages boosts interferon-β production and enhances radiotherapy effectiveness in mouse cancer models.
bioRxiv · Jan 17, 2022Cancer Biology