Intracellular K+ limits T cell exhaustion and preserves antitumor function
C. Collier, K. Wucherer, M. Mcwhorter, C. Jenkins, A. Bartlett, R. Roychoudhuri, R. Eil
This study shows that lowering intracellular K+ in T cells by disrupting Na+/K+ ATPase reduces T cell exhaustion and improves antitumor function by mitigating ROS accumulation.
bioRxiv · Sep 13, 2023Immunology