C. Copos

Model supports asymmetric regulation across the intercellular junction for collective cell polarization

The paper develops a model showing asymmetric regulation across cell-cell junctions is necessary for coordinated collective cell polarization.

Bridging global actin network patterns to local molecular dynamics: a combined modeling and machine learning framework

The paper develops a combined modeling and machine learning framework to classify actin network structures by analyzing microscale dynamics and network geometry.

Actin turnover required for adhesion-independent bleb migration

This study shows that actin turnover is necessary for bleb-based migration in rigid channels, as purely elastic actin cortex prevents effective movement.

PI3K inhibition reverses migratory direction of single cells but not cell groups in electric field

The paper shows that PI3K inhibition reverses single cell migration direction in electric fields but not in large cell groups, with different behavior observed in group interiors and edges.

Stress fibers are embedded in a contractile cortical network.

This study investigates how actin bundles are embedded in a contractile cortical network and how this affects traction force distribution in cells.

Connecting actin polymer dynamics across multiple scales

This study connects microscale actin branching dynamics to macroscale network behavior using agent-based and PDE models, showing how microscale parameters influence macroscopic growth.

A hybrid stochastic-deterministic mechanochemical model of cell polarization

The paper develops a hybrid model combining stochastic signaling and mechanical actin dynamics to explain cell polarization, showing that coupling these systems leads to stable polarization.