F. Lin

Obscured Complexity: How External Cycles Simplify the Dynamics of the Endogenous Circadian Oscillator--take the time series of body temperature records as an example

This study uses a mathematical model to simulate circadian rhythms and shows how external cycles affect the complexity and resetting behavior of the endogenous clock.

Propiconazole and Tianfengsu Regulated the Growth, Flavor, and Nutrition of Brassica rapa by Brassinosteroid Pathway

This study examines how Propiconazole and Tianfengsu affect Brassica rapa growth, flavor, and nutrition through the brassinosteroid pathway, showing synergistic benefits when used together.

Engineering PEG10 assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

This paper develops ePAC, a cancer vaccine using PEG10-based virus-like particles to deliver neoantigens and adjuvants, showing efficacy in preclinical models.

Transcriptomic and epigenetic responses shed light on soybean resistance to Phytophthora sansomeana

This study examines transcriptomic and epigenetic responses in soybean lines resistant and susceptible to Phytophthora sansomeana, identifying key genes and regulatory mechanisms involved in defense.

The exogenous application of the apocarotenoid retinaldehyde negatively regulates auxin-mediated root growth

Short-term inhibition of carotenoid biosynthesis increases retinal levels, which reduce auxin levels and signaling to suppress root growth.

Identification of B56alpha, B56gamma; and BAP1 as PRR14L binding partners

The paper identifies B56alpha, B56gamma, and BAP1 as binding partners of PRR14L, linking it to a leukemogenic complex and suggesting a scaffold role.

Lepidoptera proboscis pollens are mainly derived from nectar

The study shows that pollens on the proboscis of Lepidoptera are mainly from nectar, supporting their role in pollination and pollen germination on stigmas.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation.

This study shows that pathogen and human NDPK-proteins promote AML cell survival by activating the NLRP3-inflammasome in monocytes.

Disruption of OsLAT5 is sufficient to endow rice tolerance to dihydropyridine herbicides at commercial application concentrations

This study shows that disrupting OsLAT5 in rice confers tolerance to dihydropyridine herbicides without affecting yield or grain quality.

Oral Feeding of Nanoplastics reduces Brain function of Mice by Inducing Intestinal IL-1β-producing Macrophages

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

RBP45d is required for 5' splice site selection via binding to intronic U-rich elements and interaction with PRP39a in Arabidopsis thaliana

The study identifies RBP45d as a key regulator of 5' splice site selection in Arabidopsis by binding to intronic U-rich elements and interacting with PRP39a.

Propagation dynamics of electrotactic motility in large epithelial cell sheets

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

Intestinal Epithelial Heat Shock Protein 25/27 integrates host and microbial drivers of mucosal restitution following inflammatory injury

This study identifies Hsp25/27 as a key mediator of mucosal healing by integrating host and microbial signals in intestinal epithelial cells following inflammatory injury.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Analysis of Sexual vs Asexual Reproduction Using Four Measurements

The paper introduces four mathematical measures to compare sexual and asexual reproduction, finding that sexual reproduction leads to greater adaptability and homogeneity.

Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology

The paper shows that Slit-Robo signaling coordinates with S1P to polarize fin mesenchyme and establish fin morphology in zebrafish.

Inactivation effects of plasma-activated water on Fusarium graminearum

This study investigates how plasma-activated water (PAW) affects the viability and cellular responses of Fusarium graminearum, finding significant inhibition of microbial activity and damage to cell wall, membrane, and mitochondria.

Bacterial PxRdl2 dsRNA increased the insecticidal activities of GABAR-targeting compounds against Plutella xylostella

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

Microbial activation converts neutrophils into anti-tumor effectors

This study shows microbial bioparticles convert neutrophils into anti-tumor effectors by altering their phenotype and function, leading to tumor growth inhibition.

PI3K inhibition reverses migratory direction of single cells but not cell groups in electric field

The paper shows that PI3K inhibition reverses single cell migration direction in electric fields but not in large cell groups, with different behavior observed in group interiors and edges.

CAR Macrophages for SARS-CoV-2 Immunotherapy

This study genetically modifies human macrophages with CARs to target SARS-CoV-2, showing that CARMERTK macrophages reduce viral load without increasing proinflammatory cytokines.

A Novel Water-Soluble Photosensitizer for Photodynamic Inactivation of Gram-Positive Bacteria

This paper develops a novel water-soluble photosensitizer, sorbicillinoids, for antimicrobial photodynamic therapy that effectively inactivates Gram-positive bacteria under UV light without significant toxicity.

Genome profiles of lymphovascular breast cancer cells reveal multiple clonally differentiated outcomes with multi-regional LCM and G&T-seq

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

Similar time course of fast familiarity and slow recollection processes for recognition memory in humans and macaques

This study compares fast familiarity and slow recollection processes in humans and macaques using recognition memory tasks, finding comparable time courses across species.

Treatment of Murine Lupus with TIGIT-Ig

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

Targeting RyR2 with a phosphorylation site-specific nanobody Reverses Dysfunction of Failing Cardiomyocytes in Rat

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.