FOXO dictates initiation of B cell development and myeloid restriction in common lymphoid progenitors
L. Pena-Perez, S. Kharazi, N. Frengen, A. Krstic, T. Bouderlique, J. Hauenstein, M. He, E. Somuncular, X. Li Wang, C. Dahlberg, C. Gustafsson, A.-S. Johansson, J. Walfridsson, N. Kadri, P. S. Woll, , R. Mansson
The paper shows that FOXO1 and FOXO3 are essential for B cell development and myeloid restriction in common lymphoid progenitors, with their combined loss causing developmental block and loss of B cell lineage.
bioRxiv · Jan 21, 2022Immunology