H. Qian

ProClust provides reliable statistical significance of clusters for single-cell transcriptomic data

ProClust assesses the statistical significance of clusters in scRNA-seq data to refine overclustering and distinguish biologically meaningful subpopulations.

Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

Cell Population Growth Kinetics in the Presence of Stochastic Heterogeneity of Cell Phenotype

The paper measures growth kinetics of HL60 leukemia cell populations under stochastic phenotypic heterogeneity and develops a branching process model to explain observed variations.

EFNB1 level affects drug response in DLBCL cell lines

This study shows that EFNB1 levels influence drug response in DLBCL cell lines by affecting phosphorylation networks and sensitivity to targeted and cytotoxic drugs.

Establishment of primary renal lymphoma model and the clinical relevance

The paper establishes a novel MA-K cell line that models primary renal lymphoma and identifies biomarkers predictive of clinical outcomes in DLBCL.

Differences in self-reported benefits for student-artist versus faculty experiences in a virtual artist-in-residence program.

The paper analyzes survey data from a virtual artist-in-residence program to compare experiences and outcomes between student-artists and faculty, identifying areas for improvement and benefits.

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

Identification of GTF2IRD1 as a novel transcription factor essential for acute myeloid leukemia

This study identifies GTF2IRD1 as a novel transcription factor essential for AML cell survival and disease progression, with potential therapeutic implications.

Mechano-inhibition of Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis

The paper shows that inhibiting endocytosis with fasudil increases Fas microaggregate formation, making cancer cells more sensitive to FasL-induced apoptosis.

Skin mesenchymal niches maintain and protect AML-initiating stem cells

The paper shows skin mesenchymal niches protect AML-initiating stem cells from chemotherapy and promote chemoresistance in a mouse model.

High-density and scalable protein arrays for single-molecule proteomic studies

This paper develops a scalable method to create dense single-molecule protein arrays using DNA origami and surface functionalization, enabling high-sensitivity proteomic analysis.

FOXO dictates initiation of B cell development and myeloid restriction in common lymphoid progenitors

The paper shows that FOXO1 and FOXO3 are essential for B cell development and myeloid restriction in common lymphoid progenitors, with their combined loss causing developmental block and loss of B cell lineage.

A model for the intrinsic limit of cancer therapy: duality of treatment-induced cell death and treatment-induced stemness

This paper presents a model showing how cancer treatments can induce stemness, leading to tumor recurrence, and suggests optimizing dosing to avoid this.

Structural basis for sterol sensing by Scap and Insig

This study determines the structure of the Scap/Insig-2 complex in the absence of 25HC, revealing structural insights into cholesterol sensing and regulatory mechanisms.

Hydroxide ions amplified by water entanglement underly the mechanism of general anesthesia

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

Integrated glycoproteomics identifies a role of N-glycosylation and galectin-1 on myogenesis and muscle development

The paper identifies N-glycosylation and galectin-1 as key regulators of myogenesis and muscle development through integrated glycoproteomics and functional studies.

Structural basis for catalysis and substrate specificity of human ACAT1

The paper presents the cryo-EM structure of human ACAT1 and reveals its catalytic mechanism and substrate preference for unsaturated acyl chains.

Structure and mechanism of human diacylglycerol acyltransferase 1

This study determines the structure of hDGAT1 with a substrate, revealing its homodimeric organization and substrate-binding sites.

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

The paper reports the cryo-EM structure of tetrameric Ptch1 bound to ShhNp, revealing an asymmetric mechanism of Hh ligand inhibition.

Structure for Energy Cycle: A unique status of Second Law of Thermodynamics for living systems

The paper proposes a chemical kinetic framework for the emergence of life based on the coupling of dissipative and thermodynamic processes through inter-molecular-force-bond complexes.