ImmunologybioRxivPreprint
Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.
F. Flores-Santibanez, S. Rennen, D. Fernandez…·F. Osorio
This study shows that IRE1 RNase activity in tumor-associated dendritic cells regulates antitumor immunity, with XBP1s deficiency leading to increased tumor growth and impaired T cell responses.
DOI 10.1101/2022.07.20.500838