HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists
T. S. Strutzenberg, R. Garcia-Ordonez, S. Novick, H. Park, M. R. Chang, C. Doebellin, Y. He, R. Patouret, T. Kamenecka, P. R. Griffin
This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.
bioRxiv · Mar 26, 2019Biophysics