H. Park

An artificial intelligence accelerated virtual screening platform for drug discovery

The paper develops RosettaVS, an AI-accelerated virtual screening platform that identifies drug candidates with high binding affinity across two targets, achieving a 14% and 44% hit rate in under seven days.

Stratification of viral shedding patterns in saliva of COVID-19 patients

This study stratifies SARS-CoV-2 viral shedding patterns in saliva into three groups with distinct durations using a mathematical model and clustering, but finds no clear clinical or miRNA biomarkers explaining the differences.

β-Catenin associates with a Wnt signaling mRNA network in myeloid cells through canonical RBP binding.

The paper identifies β-catenin-associated mRNAs in myeloid cells through RIP-seq and shows MSI2 interacts with LEF1 mRNA, regulating Wnt signaling and HSPC expansion.

Single tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organelles

The paper uses single-tissue proteomics in C. elegans to identify proteins in intestinal lysosome-related organelles, revealing novel components and interorgan protein transport.

Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana

The paper determines the crystal structure of the full-length luminal part of glycosylated VSR1 from Arabidopsis thaliana, providing insights into its tertiary and quaternary structure.

Topological Learning Approach to Characterizing Biological Membranes

The paper introduces a topological learning method to predict lipid effective temperatures from static coordinates using persistent homology and machine learning.

Protein Ensemble Generation through VariationalAutoencoder Latent Space Sampling

The paper generates high-quality protein conformations using a variational autoencoder, achieving better sampling accuracy than MD simulations or AlphaFold2 for K-Ras.

Nanobead-based single-molecule pulldown for single cells

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

The Salivary Microbiome and Predicted Metabolite Production are Associated with Progression from Barrett's Esophagus to Esophageal Adenocarcinoma

This study examines the salivary microbiome and its predicted metabolite production in relation to progression from Barrett's esophagus to esophageal adenocarcinoma, finding significant microbiome shifts and metabolic changes associated with neoplastic progression.

Dysregulated Platelet Function in Patients with Post-Acute Sequelae of COVID-19

This study examines platelet function and thrombotic risk in PASC patients, finding dysregulated platelet responses and reduced thrombosis under shear conditions.

Direct Relationship between Protein Expression and Progeny Yield of Herpes Simplex Virus 1 Unveils a Rate-limiting Step for Virus Production

This study identifies a direct relationship between viral protein expression and progeny yield in herpes simplex virus 1, revealing DNA cleavage/packaging as a rate-limiting step for virus production.

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

This study develops a multiscale mathematical model to predict intrahepatic cccDNA dynamics using serum viral markers, offering a non-invasive method for HBV infection analysis.

A semiconductor 96-microplate platform for real-time impedance-based high-throughput screening

This paper introduces a semiconductor microplate platform for real-time impedance-based high-throughput screening, demonstrating its ability to profile compound mechanisms of action across diverse cell types.

Analysis of spike protein variants evolved in a novel mouse model of persistent SARS-CoV-2 infection

The paper establishes a novel mouse model of persistent SARS-CoV-2 infection using Calu-3 xenografts and identifies spike protein mutations that enhance viral replication and host adaptation.

Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution

This study shows isolation measures during the pandemic selected for SARS-CoV-2 variants with earlier and higher peak viral loads but shorter infection duration.

Advancing Glycan Analysis: A New Platform Integrating SERS, Boronic Acids, and Machine Learning Algorithms

This paper introduces a glycan detection platform combining SERS, boronic acids, and machine learning to identify and quantify glycans with high accuracy.

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease

This study investigates the role of mouse mammary tumor virus (MMTV) in colitis and dysbiosis in IL-10-/- mice, finding that MMTV contributes to disease severity and that antiretroviral therapy reduces MMTV load and improves symptoms.

Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity

This study shows Netrin-1 binding to Unc5B regulates blood-retina barrier integrity through Norrin/{beta}-catenin signaling.

Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema

This study shows keratinocytes drive secondary lymphedema by producing Th2 cytokines and that targeting their activation can reduce inflammation and swelling in mice.

Investigating the roles for essential genes in the regulation of the circadian clock in Synechococcus elongatus using CRISPR interference

This study uses CRISPR interference to investigate essential genes' roles in the circadian clock of Synechococcus elongatus, finding that reduced expression of two genes affects circadian period.

Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium

This study shows GLI2 and GLI3 regulate HBC-mediated olfactory epithelium regeneration by controlling proliferation, identity, and differentiation of HBCs following injury.

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

This study creates a mutator parasite of Plasmodium falciparum to enhance drug resistance discovery by increasing mutation rates and identifying resistance mechanisms.

Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments

This study identifies atovaquone, mefloquine, and molnupiravir as potential anti-monkeypox virus drugs, with atovaquone showing enhanced efficacy when combined with tecovirimat.

EWSR1 prevents the induction of aneuploidy by regulating the localization of Aurora B at inner centromere

This study shows that EWSR1 prevents aneuploidy by regulating Aurora B localization at inner centromeres through its interaction with Aurora B.

Single cell transcriptomics reveals functionally specialized vascular endothelium in brain

The paper uses single-cell RNA sequencing to identify reactive endothelial venules in the murine brain, revealing their role in neuroinflammation and ageing.

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases

This paper develops a method to isolate early endosomes and uses it to study amyloid precursor protein processing by β and γ-secretases in these compartments.

Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

This study identifies how CD11b agonists trigger STING-interferon signaling in tumor-associated macrophages to enhance anti-tumor immunity in mouse models and human cancer patients.

Continuous two-phase in vitro co-culture model of the enthesis

This paper develops a two-phase in vitro co-culture model of the enthesis using collagen hydrogels to study tissue development and healing mechanisms.

A new protocol for speed vernalisation of winter cereals

This paper introduces a new vernalisation protocol that significantly reduces generation time for winter cereals by combining extended photoperiod and low-temperature exposure with speed breeding conditions.