P. R. Griffin

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

This study shows that RORβ modulates a gene program that supports chondrogenesis and protects against OA by regulating FGFR signaling pathways.

This study investigates conformational changes in RORγ during DNA recognition and coregulator engagement using structural proteomics and small angle X-ray scattering.

This study uses HDX-MS and XL-MS to analyze the structural dynamics of the full-length SARS-CoV-2 nsp7:nsp8 complex, revealing conformational flexibility and a different assembly model compared to SARS-CoV.

This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.

The paper determines the structural basis of CRISPR-Cas13d's RNA-guided ribonuclease activity through cryo-EM and biochemical analysis, revealing its molecular architecture and activation mechanisms.

This study shows that bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells by inhibiting Y537S and D538G ER mutants more effectively than tamoxifen.

This study shows the Nurr1 ligand-binding domain has a dynamic, solvent-accessible pocket that can bind unsaturated fatty acids, challenging the notion that it lacks a canonical ligand-binding pocket.