Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription
A. Armache, S. Yang, L. E. Robbins, C. Durmaz, A. W. Daman, J. Q. Jeong, A. Martinez de Paz, A. Ravishankar, T. Arslan, S. Lin, T. Panchenko, B. A. Garcia, S. Hake, H. Li, C. D. Allis, S. Z. Josefowicz
The paper identifies phosphorylation of H3.3S31 in response to pathogen sensing in macrophages and shows its role in recruiting SETD2 to enhance transcription of inflammatory genes.
bioRxiv · Oct 17, 2019 · PreprintBiochemistry