S. Lin

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

TransMetaSegmentation (TMS): a transcriptome-based segmentation method for spatial metabolomic data

This paper introduces TMS, a method that combines MALDI MSI data with single-cell spatial transcriptomics to segment cells and assign metabolites to cell types.

Bola-amphiphilic dendrimer empowers imatinib to target metastatic ovarian cancer stem cells via beta-catenin-HRP2 signaling axis

This study develops a nanoformulation Bola/IM to target metastatic ovarian cancer stem cells via the beta-catenin-HRP2 signaling axis, showing improved efficacy and synergy with cisplatin.

Discovery and binding site identification of a single-stranded DNA-binding protein that interacts with double-stranded DNA

This study identifies a single-stranded DNA-binding protein from E. coli F plasmid that also binds double-stranded DNA, revealing a previously unknown dsDNA-binding capability.

Urea amidolyase as the enzyme for urea utilization in algae: functional display in Chlamydomonas reinhardtii and evolution in algae

This study identifies urea amidolyase (UAD) as the key enzyme for urea utilization in algae, showing its functional importance and evolutionary distribution in Chlamydomonas reinhardtii.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Mycelium as a scaffold for biomineralized engineered living materials

This paper demonstrates the use of fungal mycelium scaffolds mineralized by fungi or bacteria to create biomineralized engineered living materials with improved microbial viability and structural complexity.

Identification and Expression Analysis of CDPK Family in Eriobotrya japonica, reveals EjCDPK25 in Response to Freezing Stress in Fruitlets.

This study identifies and analyzes the CDPK family in loquat, finding EjCDPK25 enhances freezing stress resistance in Arabidopsis.

A robust platform for BaEVRless-lentiviral synthesis and primary natural killer cell transduction

This paper develops a robust platform for producing BaEVRless-lentiviral vectors for transducing primary natural killer cells by optimizing production in ASCT2-KO HEK293T cells.

Muscle fiber Myc is dispensable for muscle growth and forced expression severely perturbs homeostasis

This study shows that muscle fiber Myc is not required for muscle growth but its overexpression disrupts muscle structure and function.

An injury-induced tissue niche shaped by mesenchymal plasticity coordinates the regenerative and disease response in the lung

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

Comparative genomics illuminates adaptive evolution of DVNP with lifestyle and with loss of histone H1 in dinoflagellates

This study investigates the evolutionary trajectory of DVNP in dinoflagellates, linking its domestication to the loss of histone H1 and lifestyle adaptation.

Rapid QC-MS - Interactive Dashboard for Synchronous Mass Spectrometry Data Acquisition Quality Control

Rapid QC-MS provides an automated dashboard for real-time quality control of LC-MS/MS data, improving efficiency and accuracy in untargeted workflows.

Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)

This study uses scRNA-seq to analyze theanine metabolism in tea plant roots, revealing multicellular compartmentation of biosynthesis without high co-expression of transcription factors.

Small molecule inhibitor binds to NLRP3 and prevents inflammasome activation

The paper identifies that NLRP3 binds and cleaves oxidized DNA, and small molecule drugs inhibit this process to prevent inflammasome activation.

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening

This study develops a high-throughput method to generate reliable human brain organoids for modeling microcephaly, glioma invasion, and drug screening.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

This study uses CRISPR/Cas9 screens to identify SOCS1 as a target for enhancing T cell therapy, leading to the development of an engineered TIL therapy with improved anti-tumor function.

Distinct mechanisms by which antioxidant transcription factors Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of Cisplatin on hepatoma cells

This study investigates how antioxidant transcription factors Nrf1 and Nrf2 influence the anticancer effect of Cisplatin on hepatoma cells through distinct molecular mechanisms.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

Destabilization of neuromuscular junctions and deregulation of activity-dependent signalling pathways in Myotonic Dystrophy type I

This study investigates NMJ destabilization and activity-dependent signaling deregulation in DM1 mouse models, identifying CaMKII and HDAC4 as key factors in synaptic gene expression and muscle dysfunction.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

CAM5, WRKY53, and TGA5 regulate defense gene expression mediated by the volatile organic compound ethyl vinyl ketone

This paper identifies ethyl vinyl ketone (evk) as a signaling molecule in Arabidopsis thaliana, showing it activates defense genes via CAM5, WRKY53, and TGA5 through Ca2+ and H2O2 signaling.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

Species-dependent effects of seawater acidification on alkaline phosphatase activity in dinoflagellates

This study examines how pH changes affect alkaline phosphatase activity in six dinoflagellate species, revealing species-specific responses to ocean acidification.

FGFR1 governs iron metabolism via regulating post-translational modification of IRP2 in prostate cancer cells

This study shows FGFR1 promotes prostate cancer by enhancing iron metabolism through regulation of IRP2 post-translational modification and TFR1 expression.