Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits
C. E. Whyte, K. Singh, O. T. Burton, M. Aloulou, A. Moudra, C. P. Roca, F. J. Naranjo, F. Lombard-Vadnais, L. Kouser, T. Hochepied, T. Y. F. Halim, S. Schlenner, S. Lesage, J. Dooley, A. Liston
This study identifies context-dependent effects of IL-2 on immune circuits by rewiring its production sources in mice, revealing distinct cellular responses and potential adverse effects.
bioRxiv · Dec 18, 2020Immunology