Author

S. Schlenner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Liston· 2 shared A. A. Martinez· 1 shared A. Calvet· 1 shared A. D. Garg· 1 shared A. Datsi· 1 shared A. Moudra· 1 shared A. Smeets· 1 shared A. Yilmazer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

A. Liston

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development

A. Yilmazer, D. M. Zevla, R. Malmkvist, C. A. Bello Rodriguez, P. Undurraga, E. Kirgin, M. Boernert, D. Voehringer, O. Kershaw, S. Schlenner, K. Kretschmer

This study shows that peripheral Foxp3+ Treg cells can compensate for the loss of thymic Treg cells, preventing autoimmunity, but thymic Treg cells are critical for controlling beta-cell autoimmunity in type 1 diabetes.

bioRxiv · Aug 4, 2023Immunology

A lymph node-to-tumour PD-L1+macrophage circuit antagonizes dendritic cell immunotherapy

J. Sprooten, I. Vanmeerbeek, A. Datsi, J. Govaerts, D. Borras, S. Naulaerts, R. Laureano, A. Calvet, M. Kuballa, M. Sabel, M. Rapp, C. Knobbe-Thomsen, P. Liu, L. Zhao, O. Kepp, , A. D. Garg

This paper shows that DC vaccines can activate PD-L1+ macrophages in lymph nodes and tumors, creating an immunosuppressive circuit that limits their effectiveness, but this can be overcome by combining with PD-L1 blockade.

bioRxiv · Mar 14, 2023Immunology

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop

Y. Hua, G. Vella, F. Rambow, E. Allen, A. A. Martinez, M. Duhamel, S. Junius, A. Smeets, D. Nittner, D. Laoui, S. Dimmeler, T. Hehlgans, A. Liston, G. Floris, D. Lambrechts, , G. Bergers

This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.

bioRxiv · Dec 24, 2021 · PreprintCancer Biology

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

C. E. Whyte, K. Singh, O. T. Burton, M. Aloulou, A. Moudra, C. P. Roca, F. J. Naranjo, F. Lombard-Vadnais, L. Kouser, T. Hochepied, T. Y. F. Halim, S. Schlenner, S. Lesage, J. Dooley, A. Liston

This study identifies context-dependent effects of IL-2 on immune circuits by rewiring its production sources in mice, revealing distinct cellular responses and potential adverse effects.

bioRxiv · Dec 18, 2020Immunology