Author

C. Feschotte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Approach:comparative / phylogenetic analysis· 2 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Singh· 2 shared A. B. Bah· 1 shared A. Clark· 1 shared A. I. Hudson· 1 shared A. Kapusta· 1 shared A. Suh· 1 shared B. Song· 1 shared C. Sun· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersImmunology

M. Singh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers

M. Singh, S. M. Leddy, L. P. Iniguez, M. L. Bendall, C. Feschotte, D. F. Nixon

This study investigates the role of transposable elements in HIV-1 elite controllers, finding distinct transcriptomic profiles and differential TE expression associated with antiviral resistance.

bioRxiv · Dec 11, 2023Immunology

Transposable element abundance subtly contributes to lower fitness in maize

M. C. Stitzer, M. B. Khaipho-Burch, A. I. Hudson, B. Song, J. A. Valdes-Franco, G. P. Ramstein, C. Feschotte, E. S. Buckler

This study quantifies the fitness costs of transposable elements in maize by analyzing TE content across thousands of inbred lines and linking TE accumulation to reduced grain yield.

bioRxiv · Sep 18, 2023 · PreprintEvolutionary Biology

Massive invasion of organellar DNA drives nuclear genome evolution in Toxoplasma

S. Namasivayam, C. Sun, A. B. Bah, J. Oberstaller, E. Pierre-Louis, R. D. Etheridge, C. Feschotte, E. J. Pritham, J. C. Kissinger

This paper identifies extensive organellar DNA insertion into the nuclear genome of Toxoplasma gondii, revealing its role in genomic variation and potential functional impact.

bioRxiv · May 22, 2023Evolutionary Biology

Rapid evolution of piRNA clusters in the Drosophila melanogaster ovary

S. Srivastav, C. Feschotte, A. Clark

This study investigates the evolution of piRNA clusters in Drosophila melanogaster by comparing piC activity and sequence composition across strains, supporting both de novo and trap models of piC formation.

bioRxiv · May 8, 2023Evolutionary Biology

Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo

T. A. Carter, M. Singh, G. Dumbovic, J. Chobirko, J. Rinn, C. Feschotte

The paper identifies subfamilies of HERVH elements with distinct transcriptional activity in human embryos and shows a SOX2/3 binding site is essential for promoter activity in pluripotent stem cells.

bioRxiv · Jul 8, 2021Evolutionary Biology

The hidden elasticity of avian and mammalian genomes

A. Kapusta, A. Suh, C. Feschotte

The paper investigates genome size homeostasis in mammals and birds by analyzing transposable element (TE) expansion and DNA loss over 100 million years, revealing large segmental deletions as a key mechanism.

Proceedings of the National Academy of Sciences · Feb 8, 2017Peer-reviewedEvolutionary Biology