C. Sun

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

Size evolution of gigantic genomes suggests stochastic outcomes of transposable element/host silencing interactions

The paper examines TE/host interactions in salamander genomes and finds no correlation between genome size and TE deletion rates or suppression, suggesting stochastic TE accumulation in gigantic genomes.

Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus

This study develops non-β-lactam covalent allosteric inhibitors targeting PBP2a in MRSA, showing enhanced cell inhibition and antimicrobial activity against resistant strains.

Maximizing photon utilization in spectroscopic single-molecule localization microscopy using symmetrically dispersed dual-wedge prisms

This paper introduces a symmetrically dispersed dual-wedge prism design for spectroscopic single-molecule localization microscopy, improving lateral and spectral precision.

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy

This paper identifies a novel HDAC inhibitor, STR-V-53, that effectively targets HCC and enhances immunotherapy responses in mouse models.

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

This study shows that TAK1 phosphorylates PLCE1 at S1060, reducing PIP2 hydrolysis and inhibiting esophageal squamous cancer metastasis.

Phylogenomics resolves a 100-year-old debate regarding the evolutionary history of caddisflies (Insecta: Trichoptera)

This study resolves a century-old debate on caddisfly phylogeny by analyzing genome data from 111 species, clarifying the evolutionary relationships of 'cocoon-makers' and estimating divergence times.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration

This paper presents a 3D-printed composite scaffold system for bone regeneration that accelerates ECM and mineralized osteoid deposition in vivo.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

The microbial community of rust layer biofilm was driven by seawater microbial community

The paper analyzes microbial communities in rust layer biofilm and seawater, identifying dominant taxa and their interactions, and provides insights into microbial corrosion mechanisms in marine environments.

A polydiolcitrate-MoS2 composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds

This paper develops a polydiolcitrate-MoS2 composite for 3D printing bioresorbable vascular scaffolds that are X-ray visible and suitable for non-invasive monitoring.

3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty

This paper develops a drug-eluting bioresorbable vascular scaffold with reduced strut thickness and controlled drug release, showing comparable pre-clinical performance to metallic stents.

Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior

The paper develops a simulation tool using ABAQUS to analyze the crimping behavior of 3D-printed bioresorbable vascular scaffolds, enabling faster design evaluation than experimental testing.

Biomechanical stress analysis of Type-A aortic dissection at pre-dissection, post-dissection, and post-repair states

This study uses finite element analysis on CT images to analyze biomechanical stress changes in aortic dissection across pre-dissection, post-dissection, and post-repair states, revealing increased wall stress and stress concentration regions.

Deep-sea in situ and laboratory proteomics provide insights into the sulfur metabolism of a novel deep-sea bacterium, Pseudodesulfovibrio serpens sp. nov.

This study isolates and characterizes a novel deep-sea sulfate-reducing bacterium, revealing its sulfur metabolism and potential coupling with methane oxidation in deep-sea environments.

Exploring Degradation of Intrinsically Disordered Protein YAP induced by PROTACs

This study develops PROTACs to degrade YAP, showing effective tumor suppression in cancer cell lines and xenograft models.

Hormonal and transcriptomic analysis reveals the role of ABA and BR in breaking the barrier of inter-subgeneric hybridization in water lily (Nymphaea)

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

Lineage tracing of newly accrued nuclei in skeletal myofibers uncovers distinct transcripts and interplay between nuclear populations

The paper identifies distinct transcriptional states of newly fused versus pre-existing nuclei in skeletal myofibers and shows their interplay in regulating muscle growth.

Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner.

This study shows that phagocyte-expressed glycosaminoglycans mediate species-specific vascular clearance of alphaviruses, with some viruses being cleared faster than others.

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria

This study cultures a novel deep-sea Planctomycetes strain, characterizes its physiology and metabolism, and reveals nitrogen metabolism reprogramming by chronic bacteriophages.

Population ecology and potential biogeochemical impacts of ssDNA and dsDNA soil viruses along a permafrost thaw gradient

The paper analyzes ssDNA and dsDNA soil viruses along a permafrost thaw gradient to assess their ecological roles and biogeochemical impacts on carbon processing.

Species and habitat specific changes in bird activity in an urban environment during Covid 19 lockdown

The paper examines how bird activity changed during Covid-19 lockdowns in urban areas, finding species- and habitat-specific responses in three bird species.

Massive invasion of organellar DNA drives nuclear genome evolution in Toxoplasma

This paper identifies extensive organellar DNA insertion into the nuclear genome of Toxoplasma gondii, revealing its role in genomic variation and potential functional impact.

Physically informed Monte Carlo simulation of dual-wedge prism-based spectroscopic single-molecule localization microscopy

The paper develops a Monte Carlo simulation model to predict and optimize the performance of dual-wedge prism-based spectroscopic single-molecule localization microscopy systems.

Multiscale imaging of corneal endothelium damage and effects of Rho Kinase inhibitor application in mouse models of acute ocular hypertension

The paper uses multiscale imaging to study corneal endothelium damage in mouse models, finding that Rho Kinase inhibitors reduce fully-distorted tight junctions under acute ocular hypertension.