Author

G. Dumbovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

J. Rinn· 2 shared M. Looso· 2 shared M.-K. Drekolia· 2 shared S. Guenther· 2 shared T. R. Cech· 2 shared A. Papapetropoulos· 1 shared A. Weigert· 1 shared B. Blencowe· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersEvolutionary Biology

J. Rinn

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Author profile →

5 papers

Recent·Most cited

Unravelling the impact of aging on the human endothelial lncRNA transcriptome

M.-K. Drekolia, S. Talyan, R. Cordellini Emidia, R. A. Boon, S. Guenther, M. Looso, G. Dumbovic, S.-I. Bibli

This study identifies age-related changes in lncRNA expression in human endothelial cells, highlighting PCAT14 as a key regulator of endothelial function and aging.

bioRxiv · Sep 5, 2022Cell Biology

A novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

J. Hu, M. S. Leisegang, M. Looso, G. Dumbovic, J. Wittig, M.-K. Drekolia, S. Guenther, D. John, M. Siragusa, S. Zukunft, J. Oo, I. Wittig, S. Hille, A. Weigert, S. Knapp, , S. I. Bibli

This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.

bioRxiv · Sep 5, 2022 · PreprintCell Biology

Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo

T. A. Carter, M. Singh, G. Dumbovic, J. Chobirko, J. Rinn, C. Feschotte

The paper identifies subfamilies of HERVH elements with distinct transcriptional activity in human embryos and shows a SOX2/3 binding site is essential for promoter activity in pluripotent stem cells.

bioRxiv · Jul 8, 2021Evolutionary Biology

Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA transcripts is driven by intron retention: implications for RNA-directed therapies

G. Dumbovic, U. Braunschweig, H. K. K. Langner, K. Jastrzebska, M. Smallegan, B. Blencowe, T. R. Cech, M. H. Caruthers, J. L. Rinn

The paper shows that intron retention drives nuclear compartmentalization of TERT mRNA and TUG1 lncRNA, impacting cell growth and suggesting new RNA-based therapy targets.

bioRxiv · Jul 21, 2020 · PreprintCell Biology

Single-cell imaging reveals unexpected heterogeneity of TERT expression across cancer cell lines

T. Rowland, G. Dumbovic, E. P. Hass, J. Rinn, T. R. Cech

The paper uses single-molecule RNA FISH to analyze TERT expression in cancer cell lines, revealing cell-to-cell variation, complex gene expression patterns, and unexpected nuclear localization of TERT mRNA.

bioRxiv · Apr 25, 2019Cancer Biology