M. Singh

Solvatochromic reporter to image plasma membrane order leaflet by leaflet reveals ahighly asymmetric bilayer locally modulated by transbilayer interactions

The paper introduces a solvatochromic probe, C3L, to measure membrane order at the plasma membrane leaflet level, revealing asymmetry and local modulation by transbilayer interactions.

Disruption of Immune Responses By Type I Diabetes Exacerbates SARS-CoV-2 Mediated Lung Injury

This study shows that Type I Diabetes Mellitus worsens SARS-CoV-2-induced lung injury in mice by impairing immune responses and increasing inflammation.

The Streptococcus phage protein paratox is an intrinsically disordered protein.

This paper shows that the phage protein paratox is intrinsically disordered in dilute solution but folds into a globular structure when bound to ComR or in the presence of stabilizing solutes.

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens

This study overexpresses the Thchit42 gene in Pelargonium graveolens to enhance fungal resistance and plant growth, showing increased leaf size and oil content.

Tunable Macroscopic Alignment of Self-Assembling Peptide Nanofibers

This study develops a method to create aligned peptide nanofibers and shows how their alignment affects hydrogel properties and cell behavior.

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers

This study investigates the role of transposable elements in HIV-1 elite controllers, finding distinct transcriptomic profiles and differential TE expression associated with antiviral resistance.

How did UGA codon translation as tryptophan evolve in certain ciliates? A critique of Kachale et al. 2023 Nature

The paper critiques Kachale et al.'s hypothesis on UGA codon translation as tryptophan in ciliates, arguing that eRF1 substitutions are not necessary for this reassignment and presenting new tRNA data.

Conformational dynamics of a nicotinic receptor neurotransmitter site

The paper uses molecular dynamics simulations to study conformational changes in a nicotinic receptor site induced by agonists, identifying key steps in the low-to-high affinity transition.

Development and Characterization of Co-crystals Assisted with In-silico Screening for Solubility and Permeability Enhancement of Curcumin

This paper develops and characterizes co-crystals of curcumin using in-silico screening to enhance solubility and permeability, showing significant improvements in dissolution and permeability compared to pure curcumin.

Elucidation of the essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy

This study validates the essentiality of RibH in M. tb survival and identifies three potent RibH inhibitors that show antimycobacterial activity and synergy with first-line TB drugs.

Second messenger c-di-AMP regulates multiple antibiotic sensitivity pathways in Mycobacterium smegmatis by discrete mechanisms

This study shows that c-di-AMP modulates antibiotic sensitivity in M. smegmatis by interacting with protein effectors or mRNA 5-UTR regions, leading to differential drug resistance.

Global transcriptome analysis reveals Salmonella Typhimurium employs the nitrate-dependent anaerobic pathway to combat bile stress

This study identifies nitrate-dependent anaerobic metabolism as a key mechanism for Salmonella Typhimurium to survive bile stress through transcriptome analysis.

Leveraging RAS-mSIN1 Interaction to Selectively Inhibit mTORC2 Employing Competitive RAS Binding Peptide: Implications in Breast Cancer Metastasis

The paper withdraws a manuscript due to incomplete experiments and requests that it not be cited as a reference.

SifA SUMOylation governs Salmonella intracellular survival via modulation of lysosomal function

This study shows that SUMOylation of SifA in Salmonella Typhimurium is essential for intracellular survival by modulating lysosomal function and SIF formation.

Functional characterization of Salmonella Typhimurium encoded YciF, a domain of unknown function (DUF892) family protein, and its role in protection during bile and oxidative stress

This study characterizes YciF, a DUF892 domain protein in Salmonella Typhimurium, showing it functions as a ferroxidase that mitigates iron toxicity and oxidative stress during bile exposure.

Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating Wnt signaling

This study identifies ADAMTSL2 as a regulator of myogenesis by enhancing Wnt signaling, showing its role in promoting myoblast differentiation and muscle development.

Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides mechanistic insight into its role in DNA repair

This study identifies a novel interaction between RTEL1 and RPA, showing their co-localization during DNA damage and revealing structural details of HHD2 binding to RPA and DNA.

SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta

This study compares disease severity and viral load in rhesus macaques infected with SARS-CoV-2 Delta, Omicron BA.1, and BA.2 variants, finding Omicron variants cause less severe disease with lower viral loads.

Yield Prediction Through Integration of Genetic, Environment, and Management Data Through Deep Learning

This study uses deep learning to predict maize yield by integrating genetic, environmental, and management data, finding that models incorporating interactions perform best.

Site-specific analysis reveals candidate cross-kingdom small RNAs, tRNA and rRNA fragments, and signs of fungal RNA phasing in the barley-powdery mildew interaction

The paper analyzes site-specific small RNA repertoires in the barley-B. hordei interaction, identifying cross-kingdom RNA fragments and fungal phasiRNAs.

Monkey Pox Virus (MPXV): Phylogenomics, Host-Pathogen Interactome, and Mutational Cascade

This study analyzes Monkeypox virus genome sequences to investigate its phylogenomics, host-pathogen interactions, and mutational patterns, identifying key proteins and mutations associated with evolutionary dynamics and host evasion.

Biophysical, Molecular and Proteomic profiling of Human Retinal Organoids derived Exosomes

This study characterizes the biophysical, molecular, and proteomic properties of EVs from retinal organoids and compares them to hUCMSC EVs, showing superior therapeutic potential for retinal disorders.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

An AI-assisted Tool For Efficient Prostate Cancer Diagnosis

This paper develops a deep learning pipeline to detect malignant glands in prostate cancer core needle biopsies, achieving high accuracy and providing heatmaps for pathologists.

Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy

This study identifies bi-steric mTORC1-selective inhibitors that reactivate 4EBP1, suppress MYC-driven tumors, and enhance immunotherapy in multiple cancer models.

Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19

This study compares T cell responses in children and adults with mild/asymptomatic COVID-19, finding differences in T cell diversity and memory formation.

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

This study characterizes the minimal residual disease state in glioblastoma, revealing distinct evolutionary trajectories and immunomodulatory signatures associated with recurrence.

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.