Distinct oncogenes drive distinct genome and epigenome alterations in human mammary epithelial cells
C. Fonti, A. Saumet, A. Abi-Khalil, B. Orsetti, W. Jacot, E. Cleroux, A. Bender, M. Dumas, E. Schmitt, J. Colinge, M. Weber, C. Sardet, S. du Manoir, C. Theillet
This study shows that activating different oncogenes in human mammary epithelial cells leads to distinct genetic and epigenetic changes, suggesting oncogene activation shapes breast cancer subtypes.
bioRxiv · Jun 11, 2018Cancer Biology