M. Weber

MINSTED tracking of single biomolecules

The paper introduces MINSTED localization, a method for tracking labeled biomolecules with nanometer and millisecond precision using STED microscopy.

Direct optical measurement of intra-molecular distances down to the Angstrom scale

This paper demonstrates that MINFLUX fluorescence nanoscopy can measure intra-molecular distances down to 1 Angstrom with high precision, validated using known protein distances and subunit orientations.

Mannose-coupled AAV2: a second generation AAV vector for increased retinal gene therapy efficiency

This study develops a modified AAV vector with increased transduction efficiency in retinas of rats and nonhuman primates by covalently attaching mannose ligands.

Stochastic chain termination in bacterial pilus assembly

The paper reconstitutes type 1 pilus rod assembly in vitro, identifies FimI as an irreversible terminator, and models the stochastic chain termination mechanism that determines pilus length.

MINSTED nanoscopy enters the Angstrom localization range

This paper introduces MINSTED nanoscopy, achieving angstrom-scale localization of fluorophores with high precision using a STED microscope.

Evolutionary conservation of A/T-ending codons reflects co-regulation of expression and complex formation.

The paper shows that A/T-ending codons are conserved and co-regulated, enabling coordinated protein expression and complex formation across vertebrates.

Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy

This study uses cryo-electron microscopy to reveal the structural heterogeneity of keratin 5/keratin 14 filaments, showing variations in diameter and subunit organization.

Focal DNA hypo-methylation in cancer is mediated by transcription factors binding

The paper identifies transcription factors driving aberrant DNA methylation in cancer by analyzing The Cancer Genome Atlas data and validates their role in hypo-methylated regions.

Half-life of biodegradable plastics in the marine environment depends on material, habitat, and climate zone

This study assesses the biodegradation of various plastics in marine environments, finding significant variation in half-life based on material, habitat, and climate zone.

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

The paper identifies a human-derived monoclonal antibody, MTX-COVAB, with potent neutralizing activity against SARS-CoV-2 in vitro and in a hamster model, showing efficacy against variants and readiness for clinical testing.

MINSTED fluorescence localization and nanoscopy

The paper introduces MINSTED, a STED-based super-resolution microscopy method that achieves high localization precision with reduced fluorophore bleaching, and demonstrates its application in imaging Mic60 proteins in human cells.

Pore constrictions in intervessel pit membranes reduce the risk of embolism spreading in angiosperm xylem

The paper investigates how pore constrictions in pit membranes relate to embolism resistance in angiosperm xylem and finds that pit membrane thickness strongly influences constriction size and embolism resistance.

Global proteomics of Ubqln2-based murine models of ALS

The paper identifies proteomic changes in Ubqln2 mutant mice and finds that TRIM32, PEG10, and CXX1B are linked to UBQLN2 function and degradation.

Field and mesocosm methods to test biodegradable plastic film under marine conditions

This paper develops field and mesocosm methods to assess biodegradable plastic degradation in marine environments, showing PHA films disintegrate while LD-PE remains intact across different habitats and climates.

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

The paper identifies discrete populations of isotype-switched memory B cells in murine spleen and bone marrow, with distinct locations and characteristics.

Call for participation: Collaborative benchmarking of functional-structural root architecture models. The case of root water uptake.

The paper calls for collaborative benchmarking of functional-structural root architecture models to improve their accuracy and reliability in simulating root water uptake.

Effects of two seminal fluid proteins on post-mating behavior in the simultaneously hermaphroditic flatworm Macrostomum lignano

This study identifies two seminal fluid proteins in flatworms that may influence post-mating behavior, with one protein reducing partner suck behavior.

Proliferation specific codon usage facilitates oncogene translation

The paper shows that oncogenes with codon usage adapted for efficient translation in proliferative cells are more frequently mutated in cancer.

Chemosymbiotic bivalves contribute to the nitrogen budget of seagrass ecosystems

The paper investigates the role of lucinid bivalves and their symbionts in nitrogen cycling in seagrass ecosystems, finding they contribute significant ammonium to the ecosystem.

Distinct oncogenes drive distinct genome and epigenome alterations in human mammary epithelial cells

This study shows that activating different oncogenes in human mammary epithelial cells leads to distinct genetic and epigenetic changes, suggesting oncogene activation shapes breast cancer subtypes.

Development of an HPTLC method for determination of hypoglycin A in aqueous extracts of seedlings and samaras of Acer species

The paper develops and validates an HPTLC method to determine hypoglycin A levels in samaras and seedlings of Acer species, confirming its presence in A. pseudoplatanus and variability in levels.

Cell-Accurate Optical Mapping Across The Entire Developing Heart

This study maps calcium dynamics across all cells in a developing zebrafish heart to understand how structural and functional patterns emerge during organogenesis.