High throughput small molecule screening reveals NRF2-dependent and -independent pathways of cellular stress resistance
D. B. Lombard, W. Kohler, A. H. Guo, C. Gendron, M. Han, W. Ding, Y. Lyu, X. Li, X. Shi, Z. Nikolovska-Coleska, Y. Duan, T. Girke, A.-L. Hsu, S. D. Pletcher, R. S. Miller
This study identifies small molecules that induce cellular stress resistance against paraquat, cadmium, and methyl methanesulfonate, with some compounds activating Nrf2 signaling and others triggering inflammatory and AMPK pathways.
bioRxiv · Sep 22, 2019Cell Biology