M. Han

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

Mining the biosynthetic landscape of lactic acid bacteria unearths a new family of RiPPs assembled by a novel type of ThiF-like adenylyltransferases

The paper identifies a new family of RiPPs in lactic acid bacteria biosynthetic gene clusters, revealing a novel adenylyltransferase mechanism for macrocyclic imide formation.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)

This study uses scRNA-seq to analyze theanine metabolism in tea plant roots, revealing multicellular compartmentation of biosynthesis without high co-expression of transcription factors.

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

This paper develops magnetic implants paired with a wearable device to wirelessly measure biophysical and biochemical signals in rats.

Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles

This study uses super-resolution microscopy to reveal the nanoscale organization of SARS-CoV-2 replication organelles, showing distinct vgRNA and dsRNA clusters and changes over infection stages.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation

This study investigates how TGF-β1 and cholesterol interact to influence hepatocyte fate, EMT, and HSC activation in MASLD.

Nonstructural protein 1 of swine arterivirus PRRSV downregulates promyelocytic leukemia nuclear bodies and promotes viral replication

This study identifies PRRSV nsp1β as a viral protein that downregulates PML nuclear bodies by promoting PML degradation, thereby enhancing viral replication.

Electrically Conductive DNA-Inspired Coating for Intracortical Neural Microelectrodes

This paper develops a DNA-inspired conductive coating for neural microelectrodes, showing improved electrochemical performance and bio-integration compared to conventional materials.

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in normal and human mitochondrial disease models

This study identifies bacterial muropeptides as activators of ATP synthase, improving mitochondrial function and reducing stress in human cells and mice.

Expanded Multiplexing on Sensor-Constrained Microfluidic Partitioning Systems

This paper introduces an extended MLE method for microfluidic partitioning, enabling broad-range multiplexing in diagnostics using sparse Poisson recovery and ddPCR.

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages

This study shows that HIV-1 non-macrophage-tropic strains can infect macrophages through cell-to-cell transfer, overcoming entry block limitations seen in cell-free infection.

MSD2, an apoplastic Mn-SOD, contributes to root skotomorphogenic growth by modulating ROS distribution in Arabidopsis

This study identifies MSD2, an apoplastic Mn-SOD in Arabidopsis, showing it modulates ROS distribution in roots during skotomorphogenic growth.

The Siberian wild apple, Malus baccata (L.) Borkh., is an additional contributor to the genomes of cultivated European and Chinese apples

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation

This paper develops photosensitized electrospun nanofibrous filters that capture and inactivate airborne coronaviruses under visible light, achieving 99.2% capture and 98.9% inactivation of MHV-A59.

Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection

This study uses multi-color super-resolution imaging to analyze the spatial organization of coronavirus RNA during infection and assess antiviral drug effects.

Gut microbiome couples gut and brain during calorie restriction in treating obesity

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

Repression of Pdzrn3 is required for heart maturation and protects against heart failure

This study identifies Pdzrn3 as a regulator of cardiomyocyte polarization and maturation, showing its role in heart failure development and potential as a therapeutic target.

Efficient and stable metabarcoding sequencing from DNBSEQ-G400 sequencer examined by large fungal community analysis

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

Fabrication and Modeling of Recessed Traces for Silicon-Based Neural Microelectrodes

This paper develops a fabrication technique for silicon-based neural microelectrodes that recesses conductive traces to reduce insulation material degradation and presents modeling and characterization results.

Intracellular Delivery of Nanoparticles via Microelectrophoresis Technique: Feasibility demonstration

This paper demonstrates the feasibility of using microelectrophoresis to deliver nanoparticles into living cells, showing successful ejection of quantum dots into human kidney cells with minimal damage.

Intraspinal stimulation with silicon-based 3D microelectrode array for bladder voiding in cats before and after spinal cord injury

This study evaluates a 3D silicon microelectrode array for restoring bladder control in cats with spinal cord injury, showing improved responses after one month post-injury.