Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins
C. H. Peters, M. E. Myers, J. Juchno, C. Haimbaugh, H. Bichraoui, Y. Du, J. R. Bankston, L. A. Walker, C. Proenza
This paper identifies two ER proteins, LRMP and IRAG, that modulate HCN4 channel function differently, with LRMP inhibiting and IRAG enhancing HCN4 activity in a cAMP-independent manner.
bioRxiv · Apr 10, 2020Physiology