Hidden multivalency in phosphatase recruitment by a disordered AKAP scaffold
M. Watson, T. Almeida, A. Ray, C. Hanack, R. Elston, J. Btesh, P. McNaughton, K. Stott
The paper identifies additional low-affinity SLiMs in AKAP5 that, along with the canonical PxIxIT motif, contribute to a regulated signalosome through hydrophobic interactions.
bioRxiv · May 23, 2021Biophysics