K. Stott

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.

A DNA condensation code for linker histones

This study develops an in-vitro model to investigate how linker histone C-terminal tails influence chromatin condensation states through charge density, lysine/arginine ratio, and proline-free regions.

VAMP2 regulates phase separation of alpha-synuclein

This study shows that VAMP2 regulates alpha-synuclein phase separation through electrostatic interactions and lipid membrane binding, influencing its condensation and vesicle formation.

The biosynthesis, degradation, and function of cell wall β-xylosylated xyloglucan mirrors that of arabinoxyloglucan

The paper identifies enzymes involved in the biosynthesis and degradation of β-xylosylated xyloglucan and shows their potential role in gut bacterial nutrition.

LGR5 targeting molecules as therapeutic agents for multiple cancer types

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

Eudicot primary cell wall glucomannan is related in synthesis, structure and function to xyloglucan

The paper shows that β-galactoglucomannan (β-GGM) in eudicot primary cell walls is structurally and functionally similar to xyloglucan (XyG).

Hidden multivalency in phosphatase recruitment by a disordered AKAP scaffold

The paper identifies additional low-affinity SLiMs in AKAP5 that, along with the canonical PxIxIT motif, contribute to a regulated signalosome through hydrophobic interactions.

Patients with mesenchymal tumours and high Fusobacteriales prevalence have worse prognosis in colorectal cancer (CRC)