M. Watson

A pumpless and tubeless microfluidic device enables extended in vitro development of Cryptosporidium parvum

This study develops a pumpless microfluidic device for in vitro cultivation of Cryptosporidium parvum, showing extended development and infectivity of oocysts.

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest.

This study identifies functionally distinct senescent cell subpopulations based on cell cycle status, showing G2-arrested cells secrete more IL-6 and are more sensitive to senolytic treatment.

Exosomes Released from Senescent Cells and Circulatory Exosomes Isolated from Human Plasma Reveal Aging-associated Proteomic and Lipid Signatures

This study identifies aging-associated proteomic and lipid signatures in exosomes from senescent cells and human plasma, revealing shared biomarkers and pathways linked to senescence and tissue damage.

Infectious bronchitis virus vaccination, but not the presence of XCR1, is correlated with large differences in chicken caecal microbiota

This study compares the caecal microbiota of XCR1 knockout chickens with and without IBV vaccination, finding that vaccination, not XCR1 absence, significantly alters microbiota composition.

A DNA condensation code for linker histones

This study develops an in-vitro model to investigate how linker histone C-terminal tails influence chromatin condensation states through charge density, lysine/arginine ratio, and proline-free regions.

Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses

This study evaluates trihead nanoparticle immunogens to enhance cross-neutralizing antibody responses against influenza H1 viruses by combining immunofocusing techniques.

Genome-Wide Epigenomic Profiling of Primary Non-Small Cell Lung Cancer Reveals Specific and Recurrent DNA Methylation Alterations in Smoker Versus Never-Smoker Patients

This study identifies recurrent DNA methylation alterations in primary non-small cell lung cancer samples from smokers and never-smokers, highlighting differences in hypomethylation patterns and their association with oncogenes and transcription factor binding motifs.

Jaagsiekte sheep retrovirus infection induces changes in microRNA expression in the ovine lung

This study identifies differentially expressed microRNAs in JSRV-infected ovine lung, showing upregulation of miR-182, miR-183, miR-96, and miR-135b, which are associated with oncogenic pathways in human lung cancer.

Hidden multivalency in phosphatase recruitment by a disordered AKAP scaffold

The paper identifies additional low-affinity SLiMs in AKAP5 that, along with the canonical PxIxIT motif, contribute to a regulated signalosome through hydrophobic interactions.

New insights from 33,813 publicly available metagenome-assembled-genomes (MAGs) assembled from the rumen microbiome

This study catalogs and de-replicates 33,813 rumen MAGs to define putative species-level bins, highlighting the need for standardized MAG release and annotation practices.

A Kiosk Station for the Assessment of Multiple Cognitive Domains and Enrichment of Monkeys

This paper introduces a Kiosk Station for running cognitive tasks in cage-housed monkeys, showing high engagement and consistency in cognitive performance.

Metagenomic analysis of the cow, sheep, reindeer and red deer rumen

This study performs a metagenomic analysis of rumen microbiota from cattle, sheep, reindeer, and red deer, identifying novel species and core carbohydrate-active enzymes across ruminants.

Microscaled Proteogenomic Methods for Precision Oncology

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

Development of the duodenal, ileal, jejunal and caecal microbiota in chickens

This study examines the development of the chicken intestinal microbiota in four locations from day of hatch to 5 weeks of age, identifying differences in community composition, diversity, and richness over time.

A conserved role of the insulin-like signaling pathway in uric acid pathologies revealed in Drosophila melanogaster

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.

Assembly of hundreds of novel bacterial genomes from the chicken caecum

The paper assembles 469 draft bacterial genomes from chicken caecal samples, identifying 460 novel strains, 283 novel species, and 42 novel genera, and shows breed- and diet-specific microbiomes in European chickens.

Assignment of virus and antimicrobial resistance genes to microbial hosts in a complex microbial community by combined long-read assembly and proximity ligation

This study uses long-read sequencing and proximity ligation to improve the characterization of a complex cattle rumen microbial community, identifying novel viral-host associations and more antimicrobial resistance genes.

The genomic and proteomic landscape of the rumen microbiome revealed by comprehensive genome-resolved metagenomics

The paper analyzes the rumen microbiome using genome-resolved metagenomics to reveal its genomic and proteomic landscape.

Open prediction of polysaccharide utilisation loci (PUL) in 5414 public Bacteroidetes genomes using PULpy

The paper predicts polysaccharide utilisation loci (PUL) in 5414 Bacteroidetes genomes using an open-source pipeline.