A. Ray

Prior exposure to malaria decreases SARS-CoV-2 mediated mortality in K18-hACE2 mice without influencing viral load in lungs

This study shows that prior malaria exposure in K18-hACE2 mice reduces SARS-CoV-2 mortality without affecting lung viral load.

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

Membrane Mimetic-Dependence of GPCR Energy Landscapes

This study investigates how temperature affects the conformational landscape of the A2A adenosine receptor, showing drug efficacy and membrane mimetic dependence.

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

The paper identifies increased mTORC1 activity in CRSwNP epithelial cells and links it to cytokine production and inflammation in both CRSwNP and asthma.

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

Metagenomics untangles metabolic adaptations of Antarctic endolithic 1 bacteria at the fringe of habitability

The paper analyzes metagenomic data from Antarctic endolithic microbiomes to identify metabolic strategies supporting life at extreme environmental limits.

GLUT4 dynamic subcellular localization is controlled by AMP kinase activation as revealed by proximal proteome mapping in human muscle cells

The paper uses proximity mapping to show AMPK regulates GLUT4 subcellular localization in muscle cells by controlling exocytosis and endocytosis.

DksA, ppGpp and RegAB regulate nitrate respiration in Paracoccus denitrificans

This paper identifies DksA, ppGpp, and the RegAB two-component system as regulators of nitrate respiration in Paracoccus denitrificans, showing their roles in controlling NAP and Nar expression under different growth conditions.

Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition

This study shows anionic lipids facilitate GPCR-G protein complex formation through conformational selection, with computational models supporting charge complementarity as a general mechanism.

Membrane stretching activates calcium-permeability of a putative channel Pkd2 during fission yeast cytokinesis

This study shows that Pkd2, a putative ion channel in fission yeast, allows calcium influx when activated by membrane stretching during cytokinesis.

Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

This study maps phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis, showing a biphasic mesenchymal response during de-differentiation and metabolic shifts.

Comparative Structural and Dynamics Study of Free and gRNA-bound FnCas9 and SpCas9 Proteins

This study compares the structural dynamics of FnCas9 and SpCas9 proteins bound to gRNA to understand the basis of FnCas9's increased specificity.

Solvation Dynamics of a Single Triglyceride as a Function of its Chain Length

The paper investigates the solvation dynamics of single triglycerides in water and cyclohexane, analyzing how chain length affects their structure and solvation free energy.

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

Telmisartan restricts Chikungunya virus infection in vitro and in vivo through the AT1/ PPAR-γ/MAPKs pathways

This study shows Telmisartan reduces Chikungunya virus infection in vitro and in vivo by modulating host pathways including AT1/PPAR-γ/MAPKs.

MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway

This study shows that MK2 and MK3 inhibition with CMPD1 reduces CHIKV infection by blocking actin remodeling and viral release, with potential for antiviral development.

Elucidating the structural features of ABCA1 in its heterogeneous membrane environment.

This study uses molecular dynamics simulations to characterize ABCA1's conformation and lipid interactions in a heterogeneous membrane environment, revealing a continuous tunnel that supports the lateral access theory.

Hidden multivalency in phosphatase recruitment by a disordered AKAP scaffold

The paper identifies additional low-affinity SLiMs in AKAP5 that, along with the canonical PxIxIT motif, contribute to a regulated signalosome through hydrophobic interactions.

Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma

This study shows that stromal collagen structures in pancreatic ductal adenocarcinoma promote early dissemination from pre-malignant lesions and ongoing invasion, suggesting FAK inhibition or stroma normalization could limit metastasis.

Bifurcated monocyte states are predictive of mortality in severe COVID-19

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

A high throughput lipidomics method using scheduled multiple reaction monitoring

This paper introduces a high-throughput lipidomics method using scheduled multiple reaction monitoring to detect over 1000 lipid species, including structural isomers, and identifies changes in lipid composition due to Vitamin B12 deficiency.

Calcium spikes accompany the cleavage furrow ingression and cell separation during fission yeast cytokinesis

The paper identifies calcium spikes during fission yeast cytokinesis and shows they promote contractile ring constriction and daughter cell integrity.

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

Cysteine residues in the C-terminal tail of connexin32 regulate its trafficking

This study investigates how cysteine residues in the C-terminal tail of Cx32 affect its trafficking and GJ assembly, finding that specific mutations disrupt transport from the Golgi to the cell surface.

A comparative study of stress responses elicited by misfolded proteins targeted by bipartite or matrix-targeting signal sequences to yeast mitochondria

This study compares stress responses in yeast mitochondria caused by misfolded proteins targeted to the IMS or matrix using different signal sequences, revealing compartment-specific adaptations.

Docosahexaenoic acid (DHA), a nutritional supplement, modulates steroid insensitivity in asthma

This study shows DHA improves steroid sensitivity in asthma models and is lower in steroid-insensitive asthmatics.

Blimp-1 is essential for Th2 cell development and allergic asthma

This study identifies Blimp-1 as a positive regulator of Th2 cell development and allergic asthma through an IL-10-STAT3-Blimp-1 circuit.

Vibrio deploys Type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

This study identifies VPA0226, a lipase secreted by Vibrio parahaemolyticus, which esterifies cholesterol with host fatty acids to weaken the plasma membrane and enable bacterial egress from host cells.

Exosome-mediated MIR211 modulates tumor microenvironment via the DUSP6-ERK5 axis and contributes to BRAFV600E inhibitor resistance in melanoma.

This study shows MIR211 promotes melanoma growth and resistance to BRAF inhibitors by modulating the DUSP6-ERK5 axis via exosome transfer in the tumor microenvironment.