BiochemistrybioRxiv
Engineered Reversible Inhibition of SpyCatcher Reactivity Enables Rapid Generation of Bispecific Antibodies
C. Hentrich, M. Putyrski, H. Hanuschka…·F. Ylera
This paper introduces SpyLock, a reversibly inhibitable SpyCatcher variant, enabling the rapid generation of bispecific antibodies through a two-step ligation process.
DOI 10.1038/s41467-024-50296-y