Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release
C. E. Geisler, S. Ghimire, C. Hepler, K. E. Miller, M. R. Higgins, J. Yoshino, S. Klein, B. J. Renquist
This study identifies GABA as a novel hepatokine dysregulated in obesity, showing that hepatic GABA release affects serum insulin and insulin sensitivity.
bioRxiv · Apr 2, 2020Physiology