S. Ghimire

Caenorhabditis elegans model for in vivo screening of human gut microbiota mediated colonization and colonization resistance against Clostridioides difficile

This study uses C. elegans to screen human gut microbiota for colonization and resistance against C. difficile, finding 46% colonization success and 50% in vivo inhibition of C. difficile.

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

Enhancing Recovery from Gut Microbiome Dysbiosis and Alleviating DSS-Induced Colitis in Mice with a Consortium of Rare Short-Chain Fatty Acid-Producing Bacteria

The appearance of sugI mixed loci in three individuals during treatment for MDR-TB, supports the involvement of sugI in Mycobacterium tuberculosis d-cycloserine resistance in vivo.

This study identifies mixed SNPs in the sugI gene from M. tuberculosis isolates during MDR-TB treatment, suggesting a potential role of sugI in d-cycloserine resistance.

Myosin-X recruits lamellipodin to filopodia tips

The paper identifies lamellipodin as a novel cargo of myosin-X and shows it is transported to filopodia tips to support their formation and stability.

Identification of a microbial sub-community from the feral chicken gut that reduces Salmonella colonization and improves gut health in a gnotobiotic chicken model.

The paper identifies a bacterial blend from feral chicken gut microbiota that inhibits Salmonella colonization and improves gut health in chicken models.

IL-17A-mediated alterations in gut microbiota composition particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity

This study shows that IL-17A deficiency in mice leads to increased Tregs and beneficial gut microbes like Prevotella, reducing MS-like disease severity.

Rice Bran and Quercetin Produce a Positive Synergistic Effect on Human Gut Microbiota, Elevate the Level of Propionate, and Reduce the Population of Enterobacteriaceae family when Determined using a Bioreactor Model.

A model screening pipeline for bile acid converting anti-Clostridioides difficile bacteria reveals unique biotherapeutic potential of Peptacetobacter hiranonis

The paper develops a screening pipeline to identify bile acid converting bacteria with anti-C. difficile properties, isolating Peptacetobacter hiranonis with unique biotherapeutic potential.

A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity

This study shows that inhibiting hepatic GABA production in obese mice reduces hyperinsulinemia, improves glucose tolerance, and decreases food intake, suggesting a role for hepatic GABA in obesity-related metabolic dysfunction.

Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release

This study identifies GABA as a novel hepatokine dysregulated in obesity, showing that hepatic GABA release affects serum insulin and insulin sensitivity.

Description of Ruminococcus catenae SW178 sp. nov., a new anaerobic species isolated from feral chicken

The paper describes a new anaerobic bacterial species, Ruminococcus catenae, isolated from feral chickens and classified based on phylogenetic and phenotypic analysis.

Identifying Clostridioides difficile-inhibiting gut commensals using culturomics, phenotyping, and combinatorial community assembly

The paper identifies gut commensals that inhibit C. difficile using culturomics, phenotyping, and combinatorial community assembly, showing that species composition and mix size affect inhibition.

When two cells are better than one: specialized stellate cells provide a privileged route for uniquely rapid water flux in Drosophila renal tubule

The paper identifies specialized stellate cells in Drosophila renal tubules that facilitate rapid water flux through aquaporins, explaining the efficiency of insect osmoregulation.

The Gut Microbiota composition of Feral and Tamworth Pigs determined using High-Throughput Culturomics and Metagenomics Reveals Compositional Variations When Compared to the Commercial Breeds

This study compares the gut microbiota of feral and Tamworth pigs to commercial breeds using metagenomics and culturomics, revealing compositional differences and antibiotic resistance gene variation.

Description of a new member of the family Erysipelotrichaceae: Clostridium fusiformis sp. nov., isolated from healthy human feces

The paper describes a new bacterial species, Clostridium fusiformis, isolated from human feces and characterized through polyphasic analysis.

Sellimonas caecigallum sp. nov., description and genome sequence of a new member of the Sellimonas genus isolated from the cecum of feral chicken

The paper describes a new bacterial species, Sellimonas caecigallum, isolated from feral chicken cecum, based on genomic and physiological analysis.

Olsenella lakotia SW165 sp. nov., an acetate producing obligate anaerobe with a GC rich genome

The paper describes the isolation and characterization of a novel Olsenella species, Olsenella lakotia, from feral chickens, highlighting its unique genomic and metabolic features.

TMEM135 is an LXR-Inducible Regulator of Peroxisomal Metabolism

This study identifies TMEM135 as an LXR target gene that regulates peroxisomal metabolism, showing impaired β-oxidation in its knockdown.

Gut Microbial succession during conventionalization of germfree chicken

This study tracks gut microbial succession in germfree chicks inoculated with feral chicken microbiota, showing stable phylogenetic diversity and metabolic function over time.

Genome sequence and description of Blautia brookingsii str SG772 nov., a new species of anaerobic bacterium isolated from healthy human gut

The paper describes a new Blautia species, Blautia brookingsii, isolated from the human gut, based on genomic and phenotypic analyses showing significant genomic and functional differences from related species.

Whole genome sequencing-based detection of antimicrobial resistance and virulence in non-typhoidal Salmonella enterica isolated from wildlife

This study sequenced whole genomes of non-typhoidal Salmonella enterica isolates from wildlife to identify antimicrobial resistance and virulence genes.

Metagenomic characterization of the effect of feed additives on the gut microbiome and antibiotic resistome of feedlot cattle

This study examines how antibiotic feed additives affect the gut microbiome and antibiotic resistome of feedlot cattle using metagenomic sequencing.