Author

C. Himsworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

H. Muller· 2 shared J. Anderson· 2 shared J. J. Molenaar· 2 shared J. Wienke· 2 shared M. Barisa· 2 shared R. Shah· 2 shared A. C. Rios· 1 shared A. Greppi· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

H. Muller

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Detection of a reassortant swine- and human-origin H3N2 influenza A virus in farmed mink in British Columbia, Canada

K. S. Kuchinski, J. Tyson, T. Lee, S. Detmer, Y. Berhane, T. Burns, N. A. Prystajecky, C. Himsworth

The paper detects a reassortant H3N2 influenza A virus in farmed mink in British Columbia, linked to swine and human origins, highlighting zoonotic risks and the need for surveillance.

bioRxiv · May 27, 2024Microbiology

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

J. G. M. Strijker, G. Pascual-Pasto, Y. J. Kalmeijer, E. Kalaitsidou, C. Zhao, B. McIntyre, S. Matlaga, L. L. Visser, M. Barisa, C. Himsworth, R. Shah, H. Muller, L. G. Schild, P. G. Hains, Q. Zhong, , J. Wienke

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

bioRxiv · Apr 5, 2024Cancer Biology

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

M. Barisa, E. Zappa, H. Muller, R. Shah, J. Buhl, B. Draper, C. Himsworth, C. Bowers, S. Munnings-Tomes, M. Nicolaidou, S. Morlando, K. Birley, C. Leboreiro-Babe, A. Vitali, L. Privitera, , J. Anderson

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

bioRxiv · Feb 19, 2024Bioengineering