T. Lee

RfxCas13d Mediates Broad-Spectrum Suppression of Highly Pathogenic Avian Influenza

This study develops an RNA-targeting antiviral platform using RfxCas13d and demonstrates its effectiveness against multiple highly pathogenic avian influenza viruses.

Detection of a reassortant swine- and human-origin H3N2 influenza A virus in farmed mink in British Columbia, Canada

The paper detects a reassortant H3N2 influenza A virus in farmed mink in British Columbia, linked to swine and human origins, highlighting zoonotic risks and the need for surveillance.

Protein codes promote selective subcellular compartmentalization

This study introduces ProtGPS, a protein language model that predicts subcellular compartment localization and identifies mutations affecting this process.

Single nuclei sequencing reveals C4 photosynthesis is based on rewiring of ancestral cell identity networks

The paper uses single nuclei sequencing to show C4 photosynthesis evolves through rewiring of cell identity networks from C3 plants.

Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells

This study shows that deleting adhesion ligands CD54 and CD58 on allogeneic immune cells reduces NK cell rejection without impairing their anti-tumor activity.

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV

This study evaluates the immunogenicity of COVID-19 vaccines in older people with HIV and their impact on HIV reservoirs, finding that three doses are needed for optimal neutralizing responses but vaccines may increase HIV reservoirs in those with persistent viremia.

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

The paper uses MERFISH to analyze gene expression in a mouse colitis model, revealing fibroblast trajectories and spatial remodeling during inflammation.

A thermodynamic analysis of CLC transporter dimerization in lipid bilayers

This study analyzes the thermodynamics of CLC transporter dimerization in lipid bilayers, finding a large negative heat capacity change linked to solvent ordering effects.

Stress Recovery Triggers Rapid Transcriptional Reprogramming and Activation of Immunity in Plants

This study shows that drought recovery in plants rapidly activates immune responses, enhancing pathogen resistance across multiple tomato species.

Light sensitive short hypocotyl (LSH) confer symbiotic nodule identity in the legume Medicago truncatula

The paper identifies LSH1/LSH2 transcription factors as regulators of nodule identity in Medicago truncatula, distinct from lateral root identity.

Escherichia coli isolated from commercial layer hens in Australia remain susceptible to critically important antimicrobials

This study assesses antimicrobial resistance in Escherichia coli from Australian layer hens, finding low resistance rates likely due to strict antimicrobial use controls.

Non-Synonymous, Synonymous, and Non-Coding Nucleotide Variants Contribute to Recurrently Altered Biological Processes During Retinoblastoma Progression

The paper identifies contributions of non-synonymous, synonymous, and non-coding variants to recurrent biological processes in retinoblastoma progression using genomic and functional analyses.

Antimicrobial Resistance, Genomic, and Public Health Insights into Enterococcus spp. from Australian Cattle

This study examines antimicrobial resistance in enterococci from Australian cattle and finds low resistance prevalence, with bovine isolates clustering with non-vancomycin-resistant human isolates.

SIC50: Determination of IC50 by an optimized Sobel operator and a vision transformer

SIC50 uses a vision transformer and Sobel operator to determine IC50 from phase-contrast images, validated with four drugs and 1536-well plates.

FcRγ- NK cell induction by specific CMV and expansion by subclinical viral infections in rhesus macaques

This study identifies RhCMV-specific induction of FcRγ-deficient NK cells in rhesus macaques, with co-infections enhancing their frequency.

Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination

Inhaled polymer nanoparticles deliver mRNA effectively to the lung and induce protective immunity against SARS-CoV-2.

Proximity to human settlement is directly related to carriage of critically important antimicrobial-resistant Escherichia coli and Klebsiella pneumoniae in Silver Gulls

This study finds that Silver Gulls near human settlements carry more critically important antimicrobial-resistant E. coli and K. pneumoniae than those in remote areas.

Validation of selective agars for detection and quantification of Escherichia coli resistant to critically important antimicrobials

This study identifies optimal selective agars and antimicrobial combinations for detecting and quantifying resistant Escherichia coli using designed experiments and statistical analysis.

Robotic Antimicrobial Susceptibility Platform (RASP): A Next Generation Approach to One-Health Surveillance of Antimicrobial Resistance.

The paper introduces a robotic platform for high-throughput antimicrobial resistance surveillance, showing it matches human performance and identifies diverse AMR phenotypes in gut E. coli.

Two decades of creating drought tolerant maize and underpinning prediction technologies in the US corn-belt: Review and perspectives on the future of crop design

This paper reviews drought tolerant maize breeding efforts and shows increased crop improvement rates, suggesting future crop design through integrated prediction technologies.

Newly developed silicone airway stent (GINA stent): Mechanical characteristics and performance evaluation in pigs

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery

This paper develops a rapid tracheal stenosis model in pigs using cuff overpressure and electrocautery, achieving stenosis in 7 days with combined treatment.

Mycobiome analysis in fungal Infected formalin-fixed and paraffin-embedded tissues for identification of pathogenic fungi: A pilot study

This study uses nanopore sequencing on FFPE tissues to identify pathogenic fungi, finding fungal DNA in 49% of cases but noting limitations in sequencing depth and completeness.

Proximity-based proteomics reveals the thylakoid lumen proteome in the cyanobacterium Synechococcus sp. PCC 7002

This study uses proximity-based proteomics to determine the thylakoid lumen proteome in Synechococcus sp. PCC 7002, revealing proteins associated with this challenging-to-study region.

Automated measurement of long-term bower behaviors in Lake Malawi cichlids using depth sensing and action recognition

This paper develops an automated system to measure bower construction behaviors in Lake Malawi cichlids using depth sensing and action recognition, revealing non-uniform and repeatable behaviors across species and hybrids.

Transcriptional reprogramming in fused cells is triggered by plasma-membrane diminution

The paper shows that cell fusion triggers differentiation through plasma-membrane diminution, leading to transient cell starvation and activation of AMPK, which inhibits YAP1 and causes cell-cycle arrest.

C-terminal tail polyglycylation and polyglutamylation alter microtubule mechanical properties

This study investigates how polyglycylation and polyglutamylation of tubulin C-terminal tails affect microtubule stiffness and structure.

MHC genotyping from rhesus macaque exome sequences

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.