C. Zhao

An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

Single-cell resolved differentiation of pre-Kranz anatomy in maize leaf primordia

The paper uses single-nucleus RNA sequencing to study cell heterogeneity and developmental trajectories in maize leaf primordia, identifying potential regulators of Kranz anatomy development.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Single cell transcriptome profiling reveals pathogenesis of Bullous Pemphigoid

This study uses single-cell transcriptomics to identify functional changes in skin and blood cells during Bullous Pemphigoid, revealing key pathways and cell interactions involved in disease progression.

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

CrHCF244 is required for psbA translation in Chlamydomonas reinhardtii

This study identifies CrHCF244 as a psbA translation factor in Chlamydomonas, showing functional conservation with Arabidopsis HCF244 and suggesting alternative factors exist.

Alpha-defensin binding expands human adenovirus tropism

This paper shows that human adenoviruses can bind to cells via alpha-defensins instead of their usual receptors, expanding their tropism to non-susceptible cells.

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Accurate estimation of intraspecific microbial gene content variation in metagenomic data with MIDAS v3 and StrainPGC

The paper introduces StrainPGC and MIDAS v3 to accurately estimate intraspecific microbial gene content variation in metagenomic data, outperforming existing methods and revealing functional diversity in gut microbiomes.

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

Decellularization of Rat Gracilis Muscle Flap as a Potential Scaffold For Skeletal Muscle Composite Allotransplantation

This study decellularizes rat gracilis muscle flaps to create scaffolds for skeletal muscle transplantation, finding that longer decellularization reduces DNA content without compromising microcirculation.

Establishing Primary and Stable Cell Lines from Frozen Wing Biopsies for Cellular, Physiological, and Genetic Studies in Bats

This paper develops a protocol for isolating and culturing primary fibroblasts from frozen bat wing biopsies and establishes stable cell lines for genetic and physiological studies.

Development and application of GlycanDIA workflow for glycomic analysis

The paper develops GlycanDIA, a DIA-based workflow for glycan identification and quantification, showing improved sensitivity and the ability to detect low-abundant modified glycans.

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

The paper identifies genes involved in sulfur metabolism in Aspergillus fumigatus during infection, highlighting ShmB as a promising antifungal target due to its essential role in virulence and structural differences from the human enzyme.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

Ciliary length regulation by intraflagellar transport in zebrafish

This study investigates cilia length regulation in zebrafish by analyzing intraflagellar transport (IFT) speed and particle size, finding that longer cilia have faster IFT and that reducing IFT particle size shortens cilia.

Biosurfactant stabilized nanoemulsions as multifunctional magnetically targeted delivery vehicles

This paper develops biosurfactant-stabilized magnetic nanoemulsions for targeted drug delivery, showing enhanced cell uptake in cancer and macrophage cells under magnetic fields.

Comparison of urinary proteome in the first two days after mating in male rats

The paper compares the urinary proteome of male rats on the day of mating and the next day to identify proteins related to spermatogenesis.

Urine proteomic analysis of patients with schizophrenia

This study identifies 35 differential urinary proteins between unmedicated schizophrenia patients and healthy controls, with 15 linked to schizophrenia mechanisms, showing potential as diagnostic markers.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the antiviral innate immune response

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

Enhancement of Protein Stability by Quenching Millisecond Conformational Dynamics

This study links millisecond conformational dynamics of ubiquitin to protein stability through alanine mutations affecting the C-terminal retracted state.

Von Willebrand Factor Synergizes with Tumor-Derived Extracellular Vesicles to Promote Gastric Cancer Metastasis

This study shows that von Willebrand factor (VWF) and gastric cancer-derived extracellular vesicles (gcEVs) work together to promote metastasis by disrupting endothelial integrity and facilitating cancer cell migration.