Author

H. Muller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Himsworth· 2 shared J. Anderson· 2 shared J. J. Molenaar· 2 shared J. Wienke· 2 shared M. Barisa· 2 shared R. Shah· 2 shared A. Baldwin· 1 shared A. C. Rios· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

C. Himsworth

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

J. G. M. Strijker, G. Pascual-Pasto, Y. J. Kalmeijer, E. Kalaitsidou, C. Zhao, B. McIntyre, S. Matlaga, L. L. Visser, M. Barisa, C. Himsworth, R. Shah, H. Muller, L. G. Schild, P. G. Hains, Q. Zhong, , J. Wienke

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

bioRxiv · Apr 5, 2024Cancer Biology

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

M. Barisa, E. Zappa, H. Muller, R. Shah, J. Buhl, B. Draper, C. Himsworth, C. Bowers, S. Munnings-Tomes, M. Nicolaidou, S. Morlando, K. Birley, C. Leboreiro-Babe, A. Vitali, L. Privitera, , J. Anderson

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

bioRxiv · Feb 19, 2024Bioengineering

Localising elements in single-particle reconstructions by REEL-EM: Reconstructed Electron Energy-Loss - Elemental Mapping

O. Pfeil-Gardiner, H. V. D. Rosa, D. Riedel, Y. S. Chen, D. Lorks, P. Kukelhan, M. Linck, H. Muller, F. Van Petegem, B. J. Murphy

This paper introduces REEL-EM, a method combining EELS and single-particle image processing to enable elemental mapping in cryo-preserved macromolecular complexes, demonstrating reliable localization of abundant elements.

bioRxiv · Jan 18, 2024Biophysics

Somatic chromosomal integration of polydnavirus during parasitism triggered their germline infiltration in multiple lepidopteran families

C. Gilbert, C. Heisserer, H. Muller, V. Jouan, K. Musset, A.-N. Volkoff, J.-M. Drezen, G. Periquet

The paper quantifies and characterizes chromosomal integration of polydnavirus in host somatic cells and shows its recurrent germline colonization in multiple lepidopteran families.

bioRxiv · Sep 22, 2022 · PreprintEvolutionary Biology

αB-crystallin affects the morphology of Aβ(1-40) aggregates

H. Muller, D. M. Dias, A. van der Zalm, A. Baldwin

This paper introduces a protocol for producing native Aβ(1-40) with high reproducibility and shows that αB-crystallin inhibits amyloid fibril formation, favoring disordered aggregates.

bioRxiv · Mar 7, 2021 · PreprintBiochemistry