Author

C. Ingle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

K. A. Reynolds· 2 shared S. Thompson· 2 shared T. Kortemme· 1 shared T. N. Nguyen· 1 shared Y. Zhang· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

K. A. Reynolds

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2 papers

Recent·Most cited

The Genetic Landscape of a Metabolic Interaction

T. N. Nguyen, C. Ingle, S. Thompson, K. A. Reynolds

The paper quantifies how DHFR mutations affect TYMS growth rates using deep mutational scanning, revealing metabolic context's role in enzyme mutational tolerance.

bioRxiv · May 28, 2023Biochemistry

Modulating the cellular context broadly reshapes the mutational landscape of a model enzyme

S. Thompson, Y. Zhang, C. Ingle, K. A. Reynolds, T. Kortemme

The paper shows that the absence of the protease Lon in E. coli reshapes the mutational landscape of DHFR, increasing the proportion of advantageous mutations.

bioRxiv · Nov 20, 2019 · PreprintBiophysics