Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
T. N. Nguyen, C. Ingle, S. Thompson, K. A. Reynolds
The paper quantifies how DHFR mutations affect TYMS growth rates using deep mutational scanning, revealing metabolic context's role in enzyme mutational tolerance.
M. E. Di Salvo, K. A. Reynolds, M. M. Lin
The paper derives an equation showing that resonant selection pressure fluctuations exponentially accelerate fitness valley crossing in protein evolution.
J. W. McCormick, M. A. X. Russo, S. Thompson…·K. A. Reynolds
The paper investigates how mutations affect allosteric regulation by analyzing the impact of 1548 DHFR single mutations on allostery using a high-throughput assay.
S. Thompson, Y. Zhang, C. Ingle…·T. Kortemme
The paper shows that the absence of the protease Lon in E. coli reshapes the mutational landscape of DHFR, increasing the proportion of advantageous mutations.