T. N. Nguyen

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

This study shows that lipid-nanoparticle DNA vaccines encoding hemagglutinin protect pigs fully against homologous IAV-S challenge with minimal viral shedding.

This study improves neoantigen prediction by integrating RNA sequencing data with DNA sequencing to identify more immunogenic neoantigens in colorectal cancer patients.

The paper determines the cryo-EM structure of the human ULK1C core and its complex with PI3KC3-C1, revealing structural changes that suggest a mechanism for autophagy initiation through supercomplex formation.

The paper quantifies how DHFR mutations affect TYMS growth rates using deep mutational scanning, revealing metabolic context's role in enzyme mutational tolerance.

This study develops MitoPQ, a functional proteomics framework, to analyze how the UPRmt maintains mitochondrial proteostasis during stress and identifies oxidative phosphorylation as a key target.

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.

This study examines the relationship between estrogen levels and postural sway in women, finding no significant effect of menstrual cycle phase or estradiol levels on sway.

The paper determines the structure of ATG9A's C-terminal tail interacting with the ULK1 complex's ATG13:ATG101 HORMA dimer, revealing how this interaction facilitates mitophagy.

This study develops a stochastic model to analyze how antimicrobial peptides neutralize bacteria, showing that both entry and inhibition processes are critical for their effectiveness.

This study reveals that Atg4 family proteins drive autophagosome formation independently of Atg8 lipidation and protease activity, using AI-driven 3D electron microscopy.

The paper uses molecular dynamics simulations to analyze SARS-CoV-2 ACE2 variants and predicts susceptibility in red squirrels and specific mutations in dogs, rats, and mice.

This study identifies five downregulated tyrosine catabolic enzymes in HCC and links their low expression to poorer patient survival.

BiasDB compiles and analyzes known biased GPCR ligands, offering a resource for medicinal chemistry and pharmacology.

This study identifies diverse antimicrobial resistant and hypervirulent Klebsiella pneumoniae strains in South and Southeast Asia, highlighting the convergence of AMR and virulence genes.