Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice
X.-P. Wang, S. M. Mutchler, R. Carrisoza-Gaytan, M. Al-bataineh, C. J. Baty, A. Vandevender, P. Srinivasan, R. J. Tan, M. J. Jurczak, L. M. Satlin, O. B. Kashlan
This study shows that bile acid elevation in liver disease activates ENaC and causes fluid retention independently of RAAS, offering new therapeutic targets.
Journal of the American Society of Nephrology · Jul 10, 2024Peer-reviewedPhysiology