Author

X.-P. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 2 Physiology· 1

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

O. Kashlan· 2 shared P. Srinivasan· 2 shared A. Vandevender· 1 shared C. Gentilcore· 1 shared C. J. Baty· 1 shared D. M. Balchak· 1 shared L. M. Satlin· 1 shared M. Al-bataineh· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

O. Kashlan

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3 papers

Recent·Most cited

Varying selection pressure for a Na+ sensing site in epithelial Na+ channel subunits reflect divergent roles in Na+ homeostasis

X.-P. Wang, P. Srinivasan, M. El Hamdaoui, R. Grytz, O. Kashlan

The paper examines the evolution of a Na+ binding site in ENaC subunits, showing that the site is conserved in subunits but lost in delta subunits, suggesting divergent roles in Na+ homeostasis.

bioRxiv · Feb 16, 2024Evolutionary Biology

Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice

X.-P. Wang, S. M. Mutchler, R. Carrisoza-Gaytan, M. Al-bataineh, C. J. Baty, A. Vandevender, P. Srinivasan, R. J. Tan, M. J. Jurczak, L. M. Satlin, O. B. Kashlan

This study shows that bile acid elevation in liver disease activates ENaC and causes fluid retention independently of RAAS, offering new therapeutic targets.

bioRxiv · Sep 19, 2023Physiology

Activation by Cleavage of the Epithelial Na+ Channel α and γ Subunits Independently Coevolved with the Vertebrate Terrestrial Migration

X.-P. Wang, D. M. Balchak, C. Gentilcore, N. Clark, O. Kashlan

The paper shows that ENaC subunit cleavage sites coevolved with vertebrate terrestrial migration and lung development, enabling Na+ conservation and gas exchange.

bioRxiv · Oct 19, 2020Evolutionary Biology