Author

C. J. Powell

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Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

G. L. Dornan· 1 shared J. E. Burke· 1 shared J. T. Stariha· 1 shared M. J. Boulanger· 1 shared M. K. Rathinawamy· 1 shared

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2019-2019 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

G. L. Dornan

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1 paper

Recent·Most cited

BiochemistrybioRxivJul 16, 2019

Defining how oncogenic and developmental mutations of PIK3R1 alter the regulation of class IA phosphoinositide 3-kinases

G. L. Dornan, J. T. Stariha, M. K. Rathinawamy…·J. E. Burke

This study investigates how mutations in PIK3R1 affect class IA PI3K regulation, finding that oncogenic mutations hyper-activate p110 while developmental mutations reduce RTK sensitivity.

DOI 10.1016/j.str.2019.11.013

humanexperimental assay

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