Author

C. Joffre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Besson· 1 shared A. Bousard· 1 shared A. Brunel· 1 shared A. Nowosad· 1 shared C. Bosc· 1 shared C. Bousquet· 1 shared C. Callot· 1 shared C. Jean· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. Besson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer.

S. Shin, R. Nicolle, C. Jean, R. Samain, M. Ayadi, J. Raffenne, A. Brunel, J. Solorzano, C. Neuzillet, C. Joffre, S. Rocchi, J. Iovanna, N. J. Dusetti, O. Larsson, S. Pyronnet, , Y. Martineau

The paper identifies a new pancreatic cancer subtype with low protein synthesis but high integrated stress response activation, linked to metabolic impairments and drug resistance.

bioRxiv · Dec 23, 2020Cancer Biology

Mitochondrial determinants of response and resistance to venetoclax plus cytarabine duplet therapy in acute myeloid leukemia

C. Bosc, N. Gadaud, A. Bousard, M. Sabatier, G. Cognet, E. Saland, T. Farge, E. Boet, M. Gotanegre, N. Aroua, P.-L. Mouchel, C. Larrue, L. Jarrou, F. Rambow, F. Cabon, , J.-E. Sarry

This study identifies mitochondrial determinants of response and resistance to venetoclax plus cytarabine therapy in AML, showing that OxPHOS is a predictive marker and that targeting ETCI improves outcomes.

bioRxiv · Aug 17, 2020 · PreprintCancer Biology

p27 regulates the autophagy-lysosomal pathway via the control of Ragulator and mTOR activity in amino acid deprived cells

A. Nowosad, P. Jeannot, C. Callot, J. Creff, R. T. Perchey, C. Joffre, P. Codogno, S. Manenti, A. Besson

This study shows p27 regulates autophagy by controlling mTORC1 through interaction with LAMTOR1 in amino acid deprived cells.

bioRxiv · Jan 7, 2020Cell Biology