O. Larsson

SLC25A46 is in contact with lysosomes and plays a role in mitochondrial cholesterol homeostasis

This study shows SLC25A46 is required for stress-induced mitochondrial hyperfusion and involved in mitochondrial cholesterol homeostasis.

Epigenetic coordination of transcriptional and translational programs in hypoxia

The paper shows hypoxia induces TSS switching via H3K4me3 changes, altering translation of key metabolic genes like PDK1.

Amino acid usage and tRNA expression underlies proteome adaptation in Plasmodium falciparum

The paper shows that Plasmodium falciparum adjusts its tRNA profile and codon usage to adapt to amino acid availability from hemoglobin digestion, affecting protein synthesis and proliferation.

Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis

This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer.

The paper identifies a new pancreatic cancer subtype with low protein synthesis but high integrated stress response activation, linked to metabolic impairments and drug resistance.

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

This study identifies mTOR- and eIF4A-sensitive immune-related transcripts in Leishmania donovani-infected macrophages, showing their role in modulating mRNA metabolism and immune responses.

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

This study identifies mTORC1-dependent translation as a mechanism for endo-lysosome expansion and antigen presentation during phagocyte activation.

RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery

This study shows that G3BP domains are required for alphavirus replication complex clustering and translation initiation, with SFV and CHIKV relying on different G3BP domains for replication.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolomeplasticity and synergy between oncogenic kinase inhibitors and biguanides.

This study identifies translational reprogramming of non-essential amino acid synthesis and HIF1-dependent reductive glutamine metabolism as key factors enabling synergy between kinase inhibitors and biguanides in cancer cells.