Author

C. Bosc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

C. Recher· 3 shared E. Boet· 3 shared E. Saland· 3 shared F. Vergez· 3 shared J.-E. Sarry· 3 shared A. Sahal· 2 shared C. Larrue· 2 shared J. Tamburini· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

C. Recher

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

FAO-supported OxPhos leukemic stem cells are sensitive to cold.

E. Griessinger, D. Pereira-Martins, M. Nebout, C. Bosc, E. Saland, E. Boet, A. Sahal, J. Chiche, D. Debayle, L. Fleuriot, M. Pruis, V. De Mas, F. Vergez, C. Recher, G. Huls, , J.-F. Peyron

The paper identifies cold sensitivity as a vulnerability in FAO-supported OxPhos leukemic stem cells, which can be exploited for therapeutic targeting.

bioRxiv · Apr 17, 2023 · PreprintCancer Biology

VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules

S. Ramirez-Rios, S. R. Choi, C. Sanyal, T. Blum, C. Bosc, F. Krichen, E. Denarier, J.-M. Soleilhac, B. Blot, C. Janke, V. Stoppin-Mellet, M. M. Magiera, I. Arnal, M. O. Steinmetz, M.-J. Moutin

This paper shows VASH1-SVBP and VASH2-SVBP generate distinct detyrosination patterns on microtubules through different molecular mechanisms.

bioRxiv · Jun 2, 2022Cell Biology

Mitochondrial determinants of response and resistance to venetoclax plus cytarabine duplet therapy in acute myeloid leukemia

C. Bosc, N. Gadaud, A. Bousard, M. Sabatier, G. Cognet, E. Saland, T. Farge, E. Boet, M. Gotanegre, N. Aroua, P.-L. Mouchel, C. Larrue, L. Jarrou, F. Rambow, F. Cabon, , J.-E. Sarry

This study identifies mitochondrial determinants of response and resistance to venetoclax plus cytarabine therapy in AML, showing that OxPHOS is a predictive marker and that targeting ETCI improves outcomes.

bioRxiv · Aug 17, 2020 · PreprintCancer Biology

Adrenomedullin-CALCRL Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells

C. Larrue, N. Guiraud, P.-L. Mouchel, M. Dubois, T. Farge, M. Gotanegre, C. Bosc, E. Saland, M.-L. Travers-Nicolau, M. Sabatier, N. Serhan, A. Sahal, E. Boet, S. Mouche, Q. Heydt, , J.-E. Sarry

The paper identifies the ADM-CALCRL axis as a driver of drug-tolerant AML cells that persist after chemotherapy and proposes it as a therapeutic target to prevent relapse.

bioRxiv · Aug 17, 2020Cancer Biology