Lupus autoantibodies initiate a maladaptive equilibrium sustained by HMGB1:RAGE signaling and reversed by LAIR-1:C1q signaling
K. Carroll, M. Mizrachi, S. Simmons, B. Toz, J. Wingard, N. Tehrani, A. Zarfeshani, N. Kello, C. Kowal, J. Z. Levin, B. Volpe, B. Diamond
The paper models lupus-like cognitive impairment initiated by autoantibodies, showing HMGB1:RAGE signaling sustains maladaptive hippocampal injury, which is reversed by LAIR-1:C1q signaling.
bioRxiv · May 1, 2023 · PreprintImmunology